Diagnostic value of lipopolysaccharide-binding protein and procalcitonin for sepsis diagnosis in forensic pathology.

Détails

Ressource 1Télécharger: serval:BIB_1C22D7540B6C.P001 (166.45 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_1C22D7540B6C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Diagnostic value of lipopolysaccharide-binding protein and procalcitonin for sepsis diagnosis in forensic pathology.
Périodique
International Journal of Legal Medicine
Auteur(s)
Augsburger Marc, Iglesias Katia, Bardy Daniel, Mangin Patrice, Palmiere Cristian
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
127
Numéro
2
Pages
427-435
Langue
anglais
Notes
Publication types: Journal Article
Résumé
The aims of this study were twofold. The first was to investigate the diagnostic performance of two biochemical markers, procalcitonin (PCT) and lipopolysaccharide-binding protein (LBP), considering each individually and then combined, for the postmortem diagnosis of sepsis. We also tested the usefulness of pericardial fluid for postmortem LBP determination. Two study groups were formed, a sepsis-related fatalities group of 12 cases and a control group of 30 cases. Postmortem native CT scans, autopsy, histology, neuropathology, and toxicology as well as other postmortem biochemical investigations were performed in all cases. Microbiological investigations were also carried out in the septic group. Postmortem serum PCT and LBP levels differed between the two groups. Both biomarkers, individually considered, allowed septic states to be diagnosed, whereas increases in both postmortem serum PCT and LBP levels were only observed in cases of sepsis. Similarly, normal PCT and LBP values in postmortem serum were identified only in non-septic cases. Pericardial fluid LBP levels do not correlate with the presence of underlying septic states. No relationship was observed between postmortem serum and pericardial fluid LBP levels in either septic or non-septic groups, or between pericardial fluid PCT and LBP levels.
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2013 11:09
Dernière modification de la notice
01/10/2019 6:17
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