Amyotrophic lateral sclerosis.

Détails

ID Serval
serval:BIB_1C2233182EBB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Amyotrophic lateral sclerosis.
Périodique
Lancet
Auteur(s)
Mitchell J.D., Borasio G.D.
ISSN
1474-547X (Electronic)
ISSN-L
0140-6736
Statut éditorial
Publié
Date de publication
2007
Volume
369
Numéro
9578
Pages
2031-2041
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
Amyotrophic lateral sclerosis (known in the UK as motor neuron disease) is a devastating illness with uncertain pathogenesis. In this Seminar, we review its natural history, clinical features, diagnostic criteria, variant and mimic syndromes, genetic forms, and epidemiology. Several hypotheses about causes of the disorder are discussed, such as excitotoxicity and oxidant stress, and we review past and present putative disease-modifying treatments. Disease-management strategies, from telling the patient about their illness to end-of-life decisions and palliative care, are presented. We review options for control of the main symptoms of amyotrophic lateral sclerosis--including dysphagia, dysarthria, respiratory distress, pain, and psychological disorders--and care in the terminal phase. The need for good psychosocial and spiritual care of patients and families is emphasised. We conclude with an overview of some current major issues and future prospects, ranging from the search for disease markers to challenging developments such as stem-cell and gene therapy.
Mots-clé
Amyotrophic Lateral Sclerosis/diagnosis, Amyotrophic Lateral Sclerosis/physiopathology, Female, Humans, Male, Nerve Growth Factors/therapeutic use, Palliative Care, Randomized Controlled Trials as Topic, Superoxide Dismutase/genetics
Pubmed
Web of science
Création de la notice
14/01/2014 10:18
Dernière modification de la notice
03/03/2018 14:31
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