Plasma pituitary hormone levels in severe trauma with or without head injury.

Details

Serval ID
serval:BIB_1BB0AAF974F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Plasma pituitary hormone levels in severe trauma with or without head injury.
Journal
Journal of Trauma
Author(s)
Chioléro R., Lemarchand T., Schutz Y., de Tribolet N., Felber J.P., Freeman J., Jéquier E.
ISSN
0022-5282 (Print)
ISSN-L
0022-5282
Publication state
Published
Issued date
1988
Volume
28
Number
9
Pages
1368-1374
Language
english
Abstract
In order to evaluate the effect of head injury in severely traumatized patients on the response of ACTH, GH, PRL, and TSH plasma levels, 36 patients were prospectively studied over 5 consecutive days following injury. They were divided into three groups: Group I, severe isolated head injury (n = 14); Group II, multiple injury combined with severe head injury (n = 12); Group III, multiple injury without head injury (n = 10). No significant trend was observed during the 5 consecutive days. The following changes in plasma levels were observed, compared to normal reference value (median values): ACTH was normal in the three groups; PRL was elevated in Group II and normal in the other groups; GH was elevated in all groups; TSH was elevated in Group III and reduced in Groups I and II. Intergroup comparisons showed significantly lower plasma levels for PRL (p less than 0.05) and TSH (p less than 0.01) in Groups I and II, i.e., head-injured patients, compared to Group III, i.e., traumatized patients without head injury. A relationship was observed between the severity of head injury, as expressed by Glasgow Coma Score, intracranial pressure levels, outcome, and TSH and PRL levels.
Keywords
Adolescent, Adult, Craniocerebral Trauma/blood, Craniocerebral Trauma/mortality, Female, Humans, Male, Middle Aged, Multiple Trauma/blood, Multiple Trauma/mortality, Pituitary Hormones, Anterior/blood, Prognosis, Prospective Studies, Radioimmunoassay, Severity of Illness Index
Pubmed
Web of science
Create date
21/01/2008 13:07
Last modification date
20/08/2019 12:52
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