Long-term outcomes of corneal cross-linking for keratoconus in pediatric patients.

Détails

ID Serval
serval:BIB_1BA7B8A20D40
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Long-term outcomes of corneal cross-linking for keratoconus in pediatric patients.
Périodique
Journal of AAPOS
Auteur(s)
Zotta P.G., Diakonis V.F., Kymionis G.D., Grentzelos M., Moschou K.A.
ISSN
1528-3933 (Electronic)
ISSN-L
1091-8531
Statut éditorial
Publié
Date de publication
10/2017
Peer-reviewed
Oui
Volume
21
Numéro
5
Pages
397-401
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To report the long-term outcomes of corneal cross-linking (CXL) in pediatric patients with bilateral progressive keratoconus.
The medical records of consecutive pediatric patients with bilateral progressive keratoconus who underwent CXL at a single institution from June 2007to December 2009 were reviewed. All eyes underwent CXL treatment in accordance with the original Dresden protocol. Pre- and post-operative (at 1 year and >5 years after CXL) examinations included, corneal thickness (CT) at the thinnest point, corneal topographic evaluation (flat, steep meridian keratometry and maximum keratometry), with manifest refraction and corrected distance visual acuity.
A total of 20 eyes of 10 patients were included. Mean age at time of CXL was 14.34 ± 2.14 years (range, 10.49-17.09 years). Mean follow-up was 7.63 ± 1.31 years (range, 5.41-9.34 years). No intra- or postoperative complications were observed. Stabilization of all topographic indices (steep K, flat K, Kmax, and topographic cylinder) was demonstrated throughout the follow-up period (compared to preoperative topographic indices [P < 0.05]). Mean corrected distance visual acuity improved to 0.14 ± 0.16 logMAR at final follow-up from the preoperative values 0.28 ± 0.17 logMAR (P > 0.05); none of the eyes lost corrected distance visual acuity lines. Manifest refraction and mean corneal pachymetry at the thinnest point remained stable throughout the follow-up (P < 0.05).
In this case series CXL (Dresden protocol) for pediatric keratoconus halted disease progression and offered improved visual function up to 7.5 years after treatment.
Mots-clé
Adolescent, Child, Collagen/metabolism, Corneal Pachymetry, Corneal Stroma/metabolism, Corneal Topography, Cross-Linking Reagents, Female, Follow-Up Studies, Humans, Keratoconus/drug therapy, Keratoconus/metabolism, Keratoconus/physiopathology, Male, Photochemotherapy/methods, Photosensitizing Agents/therapeutic use, Refraction, Ocular/physiology, Riboflavin/therapeutic use, Treatment Outcome, Ultraviolet Rays, Visual Acuity/physiology
Pubmed
Web of science
Création de la notice
09/10/2017 10:21
Dernière modification de la notice
24/05/2018 19:07
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