Long-term outcomes of corneal cross-linking for keratoconus in pediatric patients.
Details
Serval ID
serval:BIB_1BA7B8A20D40
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-term outcomes of corneal cross-linking for keratoconus in pediatric patients.
Journal
Journal of AAPOS
ISSN
1528-3933 (Electronic)
ISSN-L
1091-8531
Publication state
Published
Issued date
10/2017
Peer-reviewed
Oui
Volume
21
Number
5
Pages
397-401
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
To report the long-term outcomes of corneal cross-linking (CXL) in pediatric patients with bilateral progressive keratoconus.
The medical records of consecutive pediatric patients with bilateral progressive keratoconus who underwent CXL at a single institution from June 2007to December 2009 were reviewed. All eyes underwent CXL treatment in accordance with the original Dresden protocol. Pre- and post-operative (at 1 year and >5 years after CXL) examinations included, corneal thickness (CT) at the thinnest point, corneal topographic evaluation (flat, steep meridian keratometry and maximum keratometry), with manifest refraction and corrected distance visual acuity.
A total of 20 eyes of 10 patients were included. Mean age at time of CXL was 14.34 ± 2.14 years (range, 10.49-17.09 years). Mean follow-up was 7.63 ± 1.31 years (range, 5.41-9.34 years). No intra- or postoperative complications were observed. Stabilization of all topographic indices (steep K, flat K, Kmax, and topographic cylinder) was demonstrated throughout the follow-up period (compared to preoperative topographic indices [P < 0.05]). Mean corrected distance visual acuity improved to 0.14 ± 0.16 logMAR at final follow-up from the preoperative values 0.28 ± 0.17 logMAR (P > 0.05); none of the eyes lost corrected distance visual acuity lines. Manifest refraction and mean corneal pachymetry at the thinnest point remained stable throughout the follow-up (P < 0.05).
In this case series CXL (Dresden protocol) for pediatric keratoconus halted disease progression and offered improved visual function up to 7.5 years after treatment.
The medical records of consecutive pediatric patients with bilateral progressive keratoconus who underwent CXL at a single institution from June 2007to December 2009 were reviewed. All eyes underwent CXL treatment in accordance with the original Dresden protocol. Pre- and post-operative (at 1 year and >5 years after CXL) examinations included, corneal thickness (CT) at the thinnest point, corneal topographic evaluation (flat, steep meridian keratometry and maximum keratometry), with manifest refraction and corrected distance visual acuity.
A total of 20 eyes of 10 patients were included. Mean age at time of CXL was 14.34 ± 2.14 years (range, 10.49-17.09 years). Mean follow-up was 7.63 ± 1.31 years (range, 5.41-9.34 years). No intra- or postoperative complications were observed. Stabilization of all topographic indices (steep K, flat K, Kmax, and topographic cylinder) was demonstrated throughout the follow-up period (compared to preoperative topographic indices [P < 0.05]). Mean corrected distance visual acuity improved to 0.14 ± 0.16 logMAR at final follow-up from the preoperative values 0.28 ± 0.17 logMAR (P > 0.05); none of the eyes lost corrected distance visual acuity lines. Manifest refraction and mean corneal pachymetry at the thinnest point remained stable throughout the follow-up (P < 0.05).
In this case series CXL (Dresden protocol) for pediatric keratoconus halted disease progression and offered improved visual function up to 7.5 years after treatment.
Keywords
Adolescent, Child, Collagen/metabolism, Corneal Pachymetry, Corneal Stroma/metabolism, Corneal Topography, Cross-Linking Reagents, Female, Follow-Up Studies, Humans, Keratoconus/drug therapy, Keratoconus/metabolism, Keratoconus/physiopathology, Male, Photochemotherapy/methods, Photosensitizing Agents/therapeutic use, Refraction, Ocular/physiology, Riboflavin/therapeutic use, Treatment Outcome, Ultraviolet Rays, Visual Acuity/physiology
Pubmed
Web of science
Create date
09/10/2017 10:21
Last modification date
20/08/2019 13:52