Early recognition of potentially fatal necrotizing fasciitis. The use of frozen-section biopsy.

Détails

ID Serval
serval:BIB_1B55CE82A0F5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Early recognition of potentially fatal necrotizing fasciitis. The use of frozen-section biopsy.
Périodique
New England Journal of Medicine
Auteur(s)
Stamenkovic I., Lew P.D.
ISSN
0028-4793[print], 0028-4793[linking]
Statut éditorial
Publié
Date de publication
1984
Volume
310
Numéro
26
Pages
1689-1693
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Necrotizing fasciitis is a rare, rapidly progressing soft-tissue infection. Early clinical recognition is difficult, and there is often a fatal delay in appropriate treatment. We evaluated the use of frozen-section biopsies for the rapid diagnosis of this disease in its early stages. Nineteen cases of necrotizing fasciitis were studied over a 13-year period. In all eight cases in which frozen-section biopsy was performed within zero to four days (average, 21 hours) after the onset of symptoms, histologic study confirmed the diagnosis, and surgical d ebridement was immediately performed. Only one patient died. In 11 patients, the diagnosis was made on clinical grounds, and surgical therapy was delayed for 1 to 15 days (average, 6) after the onset of symptoms because of failure to recognize the disorder immediately. Eight patients died (P less than 0.02). Our study indicates that rapid performance of frozen-section soft-tissue biopsy early in the evolution of a suspect lesion may provide a definitive and life-saving diagnosis.
Mots-clé
Adult, Aged, Biopsy/methods, Debridement, Fascia/ultrastructure, Fasciitis/diagnosis, Fasciitis/pathology, Female, Frozen Sections, Humans, Male, Middle Aged, Necrosis, Prognosis, Time Factors
Pubmed
Création de la notice
25/08/2010 15:52
Dernière modification de la notice
03/03/2018 14:30
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