This paper proposes an innovative framework to compare the coordination of policy sectors in an encompassing way. Building on recent contributions to the literature, this paper proposes a typology to analyze the coordination of policy sectors from a comparative perspective. To this end, the paper adapts Karl Weick’s concept of coupling to the comparative analysis of public policies, particularly to horizontal relations of policy sectors. The paper argues that it is possible to distinguish four forms of sectoral coupling: tight coupling, loose coupling, de-coupling and non-coupling. In order to demonstrate the usefulness of this typology for empirical research, the paper applies coupling to analyze the relations of the healthcare and public health sectors. To conclude, the paper discusses the possibilities and limits of the typology, and suggests other examples the approach could be transferred to.