Adult human adipose tissue contains several types of multipotent cells.

Détails

ID Serval
serval:BIB_1AEF1C300481
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Adult human adipose tissue contains several types of multipotent cells.
Périodique
Journal of Cardiovascular Translational Research
Auteur(s)
Tallone T., Realini C., Böhmler A., Kornfeld C., Vassalli G., Moccetti T., Bardelli S., Soldati G.
ISSN
1937-5395 (Electronic)
Statut éditorial
Publié
Date de publication
2011
Volume
4
Numéro
2
Pages
200-210
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
Multipotent mesenchymal stromal cells (MSCs) are a type of adult stem cells that can be easily isolated from various tissues and expanded in vitro. Many reports on their pluripotency and possible clinical applications have raised hopes and interest in MSCs. In an attempt to unify the terminology and the criteria to label a cell as MSC, in 2006 the International Society for Cellular Therapy (ISCT) proposed a standard set of rules to define the identity of these cells. However, MSCs are still extracted from different tissues, by diverse isolation protocols, are cultured and expanded in different media and conditions. All these variables may have profound effects on the selection of cell types and the composition of heterogeneous subpopulations, on the selective expansion of specific cell populations with totally different potentials and ergo, on the long-term fate of the cells upon in vitro culture. Therefore, specific molecular and cellular markers that identify MSCs subsets as well as standardization of expansion protocols for these cells are urgently needed. Here, we briefly discuss new useful markers and recent data supporting the rapidly emerging concept that many different types of progenitor cells are found in close association with blood vessels. This knowledge may promote the necessary technical improvements required to reduce variability and promote higher efficacy and safety when isolating and expanding these cells for therapeutic use. In the light of the discussed data, particularly the identification of new markers, and advances in the understanding of fundamental MSC biology, we also suggest a revision of the 2006 ISCT criteria.
Mots-clé
Adipose Tissue/blood supply, Adipose Tissue/cytology, Adult, Adult Stem Cells/metabolism, Adult Stem Cells/physiology, Biological Markers/metabolism, Cell Separation/methods, Humans, Mesenchymal Stromal Cells/metabolism, Mesenchymal Stromal Cells/physiology, Multipotent Stem Cells/metabolism, Multipotent Stem Cells/physiology, Terminology as Topic
Pubmed
Web of science
Création de la notice
06/02/2013 10:56
Dernière modification de la notice
03/03/2018 14:29
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