Restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis revisited.

Details

Serval ID
serval:BIB_1AE087940448
Type
Article: article from journal or magazin.
Collection
Publications
Title
Restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis revisited.
Journal
Familial Cancer
Author(s)
Kartheuser A., Stangherlin P., Brandt D., Remue C., Sempoux C.
ISSN
1389-9600 (Print)
ISSN-L
1389-9600
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
5
Number
3
Pages
241-60; discussion 261-2
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Since restorative proctocolectomy (RPC) with ileal-pouch anal anastomosis (IPAA) removes the entire diseased mucosa, it has become firmly established as the standard operative procedure of choice for familial adenomatous polyposis (FAP). Many technical controversies still persist, such as mesenteric lengthening techniques, close rectal wall proctectomy, endoanal mucosectomy vs. double stapled anastomosis, loop ileostomy omission and a laparoscopic approach. Despite the complexity of the operation, IPAA is safe (mortality: 0.5-1%), it carries an acceptable risk of non-life-threatening complications (10-25%), and it achieves good long-term functional outcome with excellent patient satisfaction (over 95%). In contrast to the high incidence in patients operated for ulcerative colitis (UC) (15-20%), the occurrence of pouchitis after IPAA seems to be rare in FAP patients (0-11%). Even after IPAA, FAP patients are still at risk of developing adenomas (and occasional adenocarcinomas), either in the anal canal (10-31%) or in the ileal pouch itself (8-62%), thus requiring lifelong endoscopic monitoring. IPAA operation does not jeopardise pregnancy and childbirth, but it does impair female fecundity and has a low risk of impairment of erection and ejaculation in young males. The latter can almost completely be avoided by a careful "close rectal wall" proctectomy technique. Some argue that low risk patients (e.g. <5 rectal polyps) can be identified where ileorectal anastomosis (IRA) might be reasonable. We feel that the risk of rectal cancer after IRA means that IPAA should be recommended for the vast majority of FAP patients. We accept that in some very selected cases, based on clinical and genetics data (and perhaps influenced by patient choice regarding female fecundity), a stepwise surgical strategy with a primary IPA followed at a later age by a secondary proctectomy with IPAA could be proposed.
Keywords
Adenomatous Polyposis Coli/surgery, Anal Canal/surgery, Anastomosis, Surgical, Humans, Ileum/surgery, Postoperative Complications, Pouchitis, Proctocolectomy, Restorative, Quality of Life
Pubmed
Web of science
Create date
20/10/2016 17:12
Last modification date
20/08/2019 13:51
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