Encoding dysfunctions in a dynamic-static paradigm for visuospatial working memory in first-episode psychosis patients: a 2-year follow-up study.

Détails

ID Serval
serval:BIB_1AC226F0D238
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Encoding dysfunctions in a dynamic-static paradigm for visuospatial working memory in first-episode psychosis patients: a 2-year follow-up study.
Périodique
Early Intervention In Psychiatry
Auteur(s)
Cocchi L., Debbané M., Vianin P., Bircher R., Roulin S., Conus P., Sarrasin-Bruchez P., Bovet P., Volken H., Wood S.J., Schenk F.
ISSN
1751-7893 (Electronic)
ISSN-L
1751-7885
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
3
Numéro
1
Pages
44-51
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Aim: To investigate static and dynamic visuospatial working memory (VSWM) processes in first-episode psychosis (FEP) patients and explore the validity of such measures as specific trait markers of schizophrenia. Methods: Twenty FEP patients and 20 age-, sex-, laterality- and education-matched controls carried out a dynamic and static VSWM paradigm. At 2-year follow up 13 patients met Diagnostic and Statistical Manual (of Mental Health Disorders) - Fourth Edition (DSM-IV) criteria for schizophrenia, 1 for bipolar disorder, 1 for brief psychotic episode and 5 for schizotypal personality disorder. Results: Compared with controls, the 20 FEP patients showed severe impairment in the dynamic VSWM condition but much less impairment in the static condition. No specific bias in stimulus selection was detected in the two tasks. Two-year follow-up evaluations suggested poorer baseline scores on the dynamic task clearly differentiated the 13 FEP patients who developed schizophrenia from the seven who did not. Conclusions: Results suggest deficits in VSWM in FEP patients. Specific exploratory analyses further suggest that deficit in monitoring-manipulation VSWM processes, especially involved in our dynamic VSWM task, can be a reliable marker of schizophrenia.
Mots-clé
Adult, Bipolar Disorder/physiopathology, Bipolar Disorder/psychology, Case-Control Studies, Disease Progression, Female, Humans, Male, Memory, Short-Term, Neuropsychological Tests, Psychomotor Performance/physiology, Psychotic Disorders/parasitology, Psychotic Disorders/physiopathology, Schizophrenia/physiopathology, Schizophrenic Psychology, Schizotypal Personality Disorder/physiopathology, Schizotypal Personality Disorder/psychology, Young Adult
Pubmed
Web of science
Création de la notice
27/04/2009 16:46
Dernière modification de la notice
20/08/2019 13:51
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