Notch signaling in lymphopoiesis

Détails

ID Serval
serval:BIB_1A5667CE430F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Notch signaling in lymphopoiesis
Périodique
Seminars in Immunology
Auteur(s)
Pear  W. S., Radtke  F.
ISSN
1044-5323 (Print)
Statut éditorial
Publié
Date de publication
04/2003
Volume
15
Numéro
2
Pages
69-79
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Apr
Résumé
Notch signaling regulates many cell fate decisions during development of multi-cellular organisms. Signals initiated by Notch influence a wide variety of processes that include lineage specification, cell survival and proliferation, and border formation. During development of the immune system, Notch has been shown to influence the fate of both hematopoietic stem cells (HSCs) and committed progenitors. Notch appears to play an especially important role in the development of cells that mediate acquired immunity where Notch influences multiple aspects of T and B cell development. In this review, we will focus on the potential functions of Notch signaling during lymphoid development.
Mots-clé
Animals B-Lymphocytes/immunology Cell Lineage Humans *Lymphopoiesis Membrane Proteins/*physiology Mice Models, Immunological Receptors, Notch Signal Transduction T-Lymphocytes/immunology VDJ Recombinases/metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 12:39
Dernière modification de la notice
03/03/2018 14:28
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