Cumulative Occupational Exposures and Lung-Function Decline in Two Large General-Population Cohorts.
Details
Serval ID
serval:BIB_1A500C62136E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cumulative Occupational Exposures and Lung-Function Decline in Two Large General-Population Cohorts.
Journal
Annals of the American Thoracic Society
ISSN
2325-6621 (Electronic)
ISSN-L
2325-6621
Publication state
Published
Issued date
02/2021
Peer-reviewed
Oui
Volume
18
Number
2
Pages
238-246
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Publication Status: ppublish
Abstract
Rationale: Few longitudinal studies have assessed the relationship between occupational exposures and lung-function decline in the general population with a sufficiently long follow-up.Objectives: To examine the potential association in two large cohorts: the ECRHS (European Community Respiratory Health Survey) and the SAPALDIA (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults).Methods: General-population samples of individuals aged 18 to 62 were randomly selected in 1991-1993 and followed up approximately 10 and 20 years later. Spirometry (without bronchodilation) was performed at each visit. Coded complete job histories during follow-up visits were linked to a job-exposure matrix, generating cumulative exposure estimates for 12 occupational exposures. Forced expiratory volume in 1 second (FEV <sub>1</sub> ) and forced vital capacity (FVC) were jointly modeled in linear mixed-effects models, fitted in a Bayesian framework, taking into account age and smoking.Results: A total of 40,024 lung-function measurements from 17,833 study participants were analyzed. We found accelerated declines in FEV <sub>1</sub> and the FEV <sub>1</sub> /FVC ratio for exposure to biological dust, mineral dust, and metals (FEV <sub>1</sub> = -15.1 ml, -14.4 ml, and -18.7 ml, respectively; and FEV <sub>1</sub> /FVC ratio = -0.52%, -0.43%, and -0.36%, respectively; per 25 intensity-years of exposure). These declines were comparable in magnitude with those associated with long-term smoking. No effect modification by sex or smoking status was identified. Findings were similar between the ECRHS and the SAPALDIA cohorts.Conclusions: Our results greatly strengthen the evidence base implicating occupation, independent of smoking, as a risk factor for lung-function decline. This highlights the need to prevent or control these exposures in the workplace.
Keywords
longitudinal studies, lung function, occupational disease, occupational exposure, spirometry
Pubmed
Create date
02/11/2020 13:43
Last modification date
17/02/2021 6:27