Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila.

Détails

ID Serval
serval:BIB_1A4C9EC5F9C4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila.
Périodique
BioEssays
Auteur(s)
Radtke F., Wilson A., MacDonald H.R.
ISSN
0265-9247
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
27
Numéro
11
Pages
1117-1128
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
The evolutionarily conserved Notch signaling pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. It is involved in embryonic organogenesis as well as in the maintenance of homeostasis of self-renewing systems. In this article, we review the role of Notch signaling in the hematopoietic system with particular emphasis on lymphocyte development and highlight the similarities in Notch function between Drosophila and mammalian differentiation processes. Recent studies indicating that aberrant NOTCH signaling is frequently linked to the induction of T leukemia in humans will also be discussed.
Mots-clé
Animals, Drosophila/cytology, Drosophila/embryology, Hematopoiesis, Humans, Receptors, Notch/genetics, Receptors, Notch/metabolism, Signal Transduction, Stem Cells/cytology, Stem Cells/metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 11:39
Dernière modification de la notice
20/08/2019 12:51
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