Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila.
Publication types: Journal Article ; Review Publication Status: ppublish
The evolutionarily conserved Notch signaling pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. It is involved in embryonic organogenesis as well as in the maintenance of homeostasis of self-renewing systems. In this article, we review the role of Notch signaling in the hematopoietic system with particular emphasis on lymphocyte development and highlight the similarities in Notch function between Drosophila and mammalian differentiation processes. Recent studies indicating that aberrant NOTCH signaling is frequently linked to the induction of T leukemia in humans will also be discussed.
Animals, Drosophila/cytology, Drosophila/embryology, Hematopoiesis, Humans, Receptors, Notch/genetics, Receptors, Notch/metabolism, Signal Transduction, Stem Cells/cytology, Stem Cells/metabolism
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