The offspring of the diabetic mother--short- and long-term implications.

Details

Serval ID
serval:BIB_1A471E18754F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The offspring of the diabetic mother--short- and long-term implications.
Journal
Best Practice and Research. Clinical Obstetrics and Gynaecology
Author(s)
Mitanchez D., Yzydorczyk C., Siddeek B., Boubred F., Benahmed M., Simeoni U.
ISSN
1532-1932 (Electronic)
ISSN-L
1521-6934
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
29
Number
2
Pages
256-269
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In the 1980s, David Barker and Colleagues proposed that the major causes of cardiovascular and metabolic diseases have their roots in early development. There is now robust evidence that an hyperglycemic intrauterine environment is responsible not only for significant short-term morbidity in the fetus and the neonate but also for an increased risk of developing diabetes as well as other chronic, noncommunicable diseases at adulthood. The risk is higher in pregestational diabetes, but unrecognized and/or poorly managed gestational diabetes (GDM) may have similar consequences. Although a relatively clear picture of the pathogenesis of the fetal and neonatal complications of maternal diabetes and of their interrelationship is available today, the intimate molecular mechanisms involved in the long term are far from being understood. While the rate of GDM is sharply increasing in association with the pandemic of obesity and of type 2 diabetes over the world, we review here the current understanding of short- and long-term outcomes of fetuses exposed to a diabetic environment.
Pubmed
Web of science
Create date
22/02/2015 10:37
Last modification date
21/11/2019 15:47
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