Drugs: guide and caveats to explanatory and descriptive approaches--II. Drugs in psychiatric research.

Détails

ID Serval
serval:BIB_1A43F99D7919
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Drugs: guide and caveats to explanatory and descriptive approaches--II. Drugs in psychiatric research.
Périodique
Journal of Psychiatric Research
Auteur(s)
Bollini P., Cotecchia S., De Blasi A., Romandini S., Tognoni G.
ISSN
0022-3956 (Print)
ISSN-L
0022-3956
Statut éditorial
Publié
Date de publication
1984
Volume
18
Numéro
4
Pages
391-400
Langue
anglais
Résumé
Over the last two decades animal models, mediators and drugs have produced a mass of experimental data difficult to relate to the epidemiological and clinical side of psychiatric disorders. Antidepressant drugs are chosen as a model case to describe a more general scene: far from being a specific tool--a guide--in a complex situation, these drugs are acquiring a role which must be interpreted with caution (a caveat), in view of ample clinical evidence of responders to placebo, responders to any drugs, responders to many drugs, etc. Studies of biochemical descriptors of drug action as a marker of the disease and its outcome have drawn puzzling pictures, often contradictory and unstable in terms of the populations to whom they can be applied. Controlled clinical trials with antidepressant drugs over the last ten years have persisted in looking for short-term pharmacological effects rather than the medium- or long-term impact of medication in large populations. To establish a positive role for antidepressant drugs, they must be studied in a "natural" context where depressed patients are treated with all necessary follow-up.
Mots-clé
Animals, Antidepressive Agents/blood, Antidepressive Agents/therapeutic use, Depressive Disorder/drug therapy, Disease Models, Animal, Drug Evaluation/standards, Drug Evaluation, Preclinical/standards, Genetic Markers, Humans, Models, Neurological, Molecular Biology, Research Design
Pubmed
Web of science
Création de la notice
24/01/2008 12:05
Dernière modification de la notice
03/03/2018 14:28
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