Improvement in coronary circulatory function in morbidly obese individuals after gastric bypass-induced weight loss: relation to alterations in endocannabinoids and adipocytokines.

Détails

ID Serval
serval:BIB_19B1E4553846
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Improvement in coronary circulatory function in morbidly obese individuals after gastric bypass-induced weight loss: relation to alterations in endocannabinoids and adipocytokines.
Périodique
European Heart Journal
Auteur(s)
Quercioli A., Montecucco F., Pataky Z., Thomas A., Ambrosio G., Staub C., Di Marzo V., Ratib O., Mach F., Golay A., Schindler T.H.
ISSN
1522-9645 (Electronic)
ISSN-L
0195-668X
Statut éditorial
Publié
Date de publication
2013
Volume
34
Numéro
27
Pages
2063-2073
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
AIMS: To investigate the effect of surgical gastric bypass-induced weight loss and related alterations in endocannabinoids (ECs) and adipocytokine plasma levels on coronary circulatory dysfunction in morbidly obese (MOB) individuals.
METHODS AND RESULTS: Myocardial blood flow (MBF) responses to cold pressor test (CPT) from rest (ΔMBF) and during pharmacologically induced hyperaemia were measured with ¹³N-ammonia PET/CT in 18 MOB individuals with a body mass index (BMI) > 40 kg/m² at baseline and after a median follow-up period of 22 months. Gastric bypass intervention decreased BMI from a median of 44.8 (inter-quartile range: 43.3, 48.2) to 30.8 (27.3, 34.7) kg/m² (P < 0.0001). This decrease in BMI was accompanied by a marked improvement in endothelium-related ΔMBF to CPT and hyperaemic MBFs, respectively [0.34 (0.18, 0.41) from 0.03 (-0.08, 0.15) mL/g/min, P = 0.002; and 2.51 (2.17, 2.64) from 1.53 (1.39, 2.18) mL/g/min, P < 0.001]. There was an inverse correlation between decreases in plasma concentrations of the EC anandamide and improvement in ΔMBF to CPT (r = -0.59, P = 0.009), while increases in adiponectin plasma levels correlated positively with hyperaemic MBFs (r = 0.60, P = 0.050). Conversely, decreases in leptin plasma concentrations were not observed to correlate with the improvement in coronary circulatory function (r = 0.22, P = 0.400, and r = -0.31, P = 0.250).
CONCLUSIONS: Gastric bypass-related reduction of BMI in MOB individuals beneficially affects coronary circulatory dysfunction. The dysbalance between ECs and adipocytokines appears to be an important determinant of coronary circulatory function in obesity.
Mots-clé
Adipokines/metabolism, Adipose Tissue/metabolism, Adult, Coronary Circulation/physiology, Endocannabinoids/metabolism, Female, Gastric Bypass, Hemodynamics/physiology, Humans, Male, Obesity, Morbid/physiopathology, Obesity, Morbid/surgery, Positron-Emission Tomography, Prospective Studies, Stress, Physiological, Tomography, X-Ray Computed, Vasomotor System/physiology, Weight Loss/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2015 16:50
Dernière modification de la notice
20/08/2019 12:50
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