A population-based approach to assess the heritability and distribution of renal handling of electrolytes.

Détails

ID Serval
serval:BIB_19A74BF47D89
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A population-based approach to assess the heritability and distribution of renal handling of electrolytes.
Périodique
Kidney international
Auteur(s)
Moulin F., Ponte B., Pruijm M., Ackermann D., Bouatou Y., Guessous I., Ehret G., Bonny O., Pechère-Bertschi A., Staessen J.A., Paccaud F., Martin P.Y., Burnier M., Vogt B., Devuyst O., Bochud M.
ISSN
1523-1755 (Electronic)
ISSN-L
0085-2538
Statut éditorial
Publié
Date de publication
12/2017
Peer-reviewed
Oui
Volume
92
Numéro
6
Pages
1536-1543
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The handling of electrolytes by the kidney is essential for homeostasis. However, the heritability of these processes, the first step in gene discovery, is poorly known. To help clarify this, we estimated the heritability of serum concentration, urinary excretion, renal clearance, and fractional excretion of sodium, potassium, magnesium, calcium, phosphate, and chloride in a population-based study. Nuclear families were randomly selected from the general population in Lausanne, Geneva, and Bern, Switzerland, and urine collected over 24-hour periods. We used the ASSOC program (S.A.G.E.) to estimate narrow sense heritability, including sex, age, body mass index, and study center as covariates in the model. The 1128 participants, from 273 families, had a mean age of 47 years, body mass index of 25.0 kg/m <sup>2</sup> , and an estimated glomerular filtration rate (CKD-EPI) of 98 mL/min/1.73 m <sup>2</sup> . The heritability of serum concentration was highest for calcium, 37% and lowest for sodium, 13%. The heritability of 24-hour urine clearances, excretions, and fractional excretions ranged from 15%, 10%, and 16%, respectively, for potassium to 45%, 44%, and 51%, respectively, for calcium. All probability values were significant. The heritability for phosphate-related phenotypes was lower than that for calcium. Thus, the serum and urine concentrations as well as urinary excretion and renal handling of electrolytes are heritable in the general adult population. The phenotypic variance attributable to additive genetic factors was variable and was higher for calcium. These results pave the way for identifying genetic variants involved in electrolyte homeostasis in the general population.
Mots-clé
Adult, Cohort Studies, Computational Biology, Electrolytes/blood, Electrolytes/metabolism, Electrolytes/urine, Female, Glomerular Filtration Rate, Homeostasis/genetics, Humans, Kidney/physiopathology, Male, Middle Aged, Pedigree, Phenotype, Renal Elimination/genetics, Software, Switzerland, heritability, population, renal function, urinary phenotypes
Pubmed
Web of science
Création de la notice
21/09/2017 15:20
Dernière modification de la notice
20/08/2019 12:50
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