Article: article from journal or magazin.
Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade.
Publication types: JOURNAL ARTICLE Publication Status: ppublish. pdf type: Author's View
We have recently reported that the PD-1 and CTLA4 signaling pathways are active in both effector and regulatory T cells, causing profound immune dysfunctions in the tumor microenvironment. In line with this notion, the dual blockade of PD-1- and CTLA4-conveyed signals may exert robust therapeutic effects. Here, we discuss the mechanisms possibly underlying such a synergic interaction.
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