Article: article from journal or magazin.
GABA receptor subunits in human auditory cortex in normal and stroke cases.
Acta Neurobiologiae Experimentalis
GABA receptors are ubiquitous in the cerebral cortex and play a major role in shaping responses of cortical neurons. GABAA and GABAB receptor subunit expression was visualized by immunohistochemistry in human auditory areas from both hemispheres in 9 normal subjects (aged 43-85 years; time between death and fixation 6-24 hours) and in 4 stroke patients (aged 59-87 years; time between death and fixation 7-24 hours) and analyzed qualitatively for GABAA and semiquantitatively for GABAB receptor subunits. In normal brains, the primary auditory area (TC) and the surrounding areas TB and TA displayed distinct GABAA receptor subunit labeling with differences among cortical layers and areas. In postacute and chronic stroke we found a layer-selective downregulation of the alpha-2 subunit in the anatomically intact cerebral cortex of the intact and of the lesioned hemisphere, whereas the alpha-1, alpha-3 and beta-2/3 subunits maintained normal levels of expression. The GABAB receptors had a distinct laminar pattern in auditory areas and minor differences among areas. Unlike in other pathologies, there is no modulation of the GABAB receptor expression in subacute or chronic stroke.
GABA, Human, Postlesional Plasticity, Diaschisis, Auditory, Temporal-Lobe Epilepsy, Electrophysiological Transcortical Diaschisis, Learning-Induced Plasticity, Extrastriate Visual-Cortex, Focal Hemispheric Lesions, Human Superior Colliculus, Calcium-Binding Proteins, Central-Nervous-System, Human Cerebral-Cortex, Cytochrome-Oxidase
Web of science
Last modification date