Pro-opiomelanocortin gene and melanin-based colour polymorphism in a reptile

Détails

Ressource 1Télécharger: BIB_18D006C326F9.P001.pdf (803.80 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_18D006C326F9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pro-opiomelanocortin gene and melanin-based colour polymorphism in a reptile
Périodique
Biological Journal of the Linnean Society
Auteur(s)
Ducrest A.L., Ursenbacher S., Golay P., Monney J.C., Mebert K., Roulin A., Dubey S.
ISSN
0024-4066
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
111
Numéro
1
Pages
160-168
Langue
anglais
Résumé
Colour polymorphism is widespread among vertebrates and plays important roles in prey-predator interactions, thermoregulation, social competition, and sexual selection. However, the genetic mechanisms involved in colour variation have been studied mainly in domestic mammals and birds, whereas information on wild animals remains scarce. Interestingly, the pro-opiomelanocortin gene (POMC) gives rise to melanocortin hormones that trigger melanogenesis (by binding the melanocortin-1-receptor; Mc1r) and other physiological and behavioural functions (by binding the melanocortin receptors Mc1-5rs). Owing to its pleiotropic effect, the POMC gene could therefore account for the numerous covariations between pigmentation and other phenotypic traits. We screened the POMC and Mc1r genes in 107 wild asp vipers (Vipera aspis) that can exhibit four discrete colour morphs (two unpatterned morphs: concolor or melanistic; two patterned morphs: blotched or lined) in a single population. Our study revealed a correlation between a single nucleotide polymorphism situated within the 3-untranslated region of the POMC gene and colour variation, whereas Mc1r was not found to be polymorphic. To the best of our knowledge, we disclose for the first time a relationship between a mutation at the POMC gene and coloration in a wild animal, as well as a correlation between a genetic marker and coloration in a snake species. Interestingly, similar mutations within the POMC 3-untranslated region are linked to human obesity and alcohol and drug dependence. Combined with our results, this suggests that the 3-untranslated region of the POMC gene may play a role in its regulation in distant vertebrates.
Mots-clé
Mc1r, melanocortin-1-receptor gene, melanogenesis, POMC, snake, Vipera aspis
Web of science
Open Access
Oui
Création de la notice
20/08/2013 11:58
Dernière modification de la notice
20/08/2019 12:49
Données d'usage