Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups

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Serval ID
serval:BIB_1874591F7867
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups
Journal
American Journal of Psychiatry
Author(s)
Boedhoe Premika S.W., van Rooij Daan, Hoogman Martine, Twisk Jos W.R., Schmaal Lianne, Abe Yoshinari, Alonso Pino, Ameis Stephanie H., Anikin Anatoly, Anticevic Alan, Arango Celso, Arnold Paul D., Asherson Philip, Assogna Francesca, Auzias Guillaume, Banaschewski Tobias, Baranov Alexander, Batistuzzo Marcelo C., Baumeister Sarah, Baur-Streubel Ramona, Behrmann Marlene, Bellgrove Mark A., Benedetti Francesco, Beucke Jan C., Biederman Joseph, Bollettini Irene, Bose Anushree, Bralten Janita, Bramati Ivanei E., Brandeis Daniel, Brem Silvia, Brennan Brian P., Busatto Geraldo F., Calderoni Sara, Calvo Anna, Calvo Rosa, Castellanos Francisco X., Cercignani Mara, Chaim-Avancini Tiffany M., Chantiluke Kaylita C., Cheng Yuqi, Cho Kang Ik K., Christakou Anastasia, Coghill David, Conzelmann Annette, Cubillo Ana I., Dale Anders M., Dallaspezia Sara, Daly Eileen, Denys Damiaan, Deruelle Christine, Di Martino Adriana, Dinstein Ilan, Doyle Alysa E., Durston Sarah, Earl Eric A., Ecker Christine, Ehrlich Stefan, Ely Benjamin A., Epstein Jeffrey N., Ethofer Thomas, Fair Damien A., Fallgatter Andreas J., Faraone Stephen V., Fedor Jennifer, Feng Xin, Feusner Jamie D., Fitzgerald Jackie, Fitzgerald Kate D., Fouche Jean-Paul, Freitag Christine M., Fridgeirsson Egill A., Frodl Thomas, Gabel Matt C., Gallagher Louise, Gogberashvili Tinatin, Gori Ilaria, Gruner Patricia, Gürsel Deniz A., Haar Shlomi, Haavik Jan, Hall Geoffrey B., Harrison Neil A., Hartman Catharina A., Heslenfeld Dirk J., Hirano Yoshiyuki, Hoekstra Pieter J., Hoexter Marcelo Q., Hohmann Sarah, Høvik Marie F., Hu Hao, Huyser Chaim, Jahanshad Neda, Jalbrzikowski Maria, James Anthony, Janssen Joost, Jaspers-Fayer Fern, Jernigan Terry L., Kapilushniy Dmitry, Kardatzki Bernd, Karkashadze Georgii, Kathmann Norbert, Kaufmann Christian, Kelly Clare, Khadka Sabin, King Joseph A., Koch Kathrin, Kohls Gregor, Konrad Kerstin, Kuno Masaru, Kuntsi Jonna, Kvale Gerd, Kwon Jun Soo, Lázaro Luisa, Lera-Miguel Sara, Lesch Klaus-Peter, Hoekstra Liesbeth, Liu Yanni, Lochner Christine, Louza Mario R., Luna Beatriz, Lundervold Astri J., Malpas Charles B., Marques Paulo, Marsh Rachel, Martínez-Zalacaín Ignacio, Mataix-Cols David, Mattos Paulo, McCarthy Hazel, McGrath Jane, Mehta Mitul A., Menchón José M., Mennes Maarten, Martinho Mauricio Moller, Moreira Pedro S., Morer Astrid, Morgado Pedro, Muratori Filippo, Murphy Clodagh M., Murphy Declan G.M., Nakagawa Akiko, Nakamae Takashi, Nakao Tomohiro, Namazova-Baranova Leyla, Narayanaswamy Janardhanan C., Nicolau Rosa, Nigg Joel T., Novotny Stephanie E., Nurmi Erika L., Weiss Eileen Oberwelland, O'Gorman Tuura Ruth L., O'Hearn Kirsten, O'Neill Joseph, Oosterlaan Jaap, Oranje Bob, Paloyelis Yannis, Parellada Mara, Pauli Paul, Perriello Chris, Piacentini John, Piras Fabrizio, Piras Federica, Plessen Kerstin J., Puig Olga, Ramos-Quiroga J. Antoni, Reddy Y.C. Janardhan, Reif Andreas, Reneman Liesbeth, Retico Alessandra, Rosa Pedro G.P., Rubia Katya, Rus Oana Georgiana, Sakai Yuki, Schrantee Anouk, Schwarz Lena, Schweren Lizanne J.S., Seitz Jochen, Shaw Philip, Shook Devon, Silk Tim J., Simpson H. Blair, Skokauskas Norbert, Soliva Vila Juan Carlos, Solovieva Anastasia, Soreni Noam, Soriano-Mas Carles, Spalletta Gianfranco, Stern Emily R., Stevens Michael C., Stewart S. Evelyn, Sudre Gustavo, Szeszko Philip R., Tamm Leanne, Taylor Margot J., Tolin David F., Tosetti Michela, Tovar-Moll Fernanda, Tsuchiyagaito Aki, van Erp Theo G.M., van Wingen Guido A., Vance Alasdair, Venkatasubramanian Ganesan, Vilarroya Oscar, Vives-Gilabert Yolanda, von Polier Georg G., Walitza Susanne, Wallace Gregory L., Wang Zhen, Wolfers Thomas, Yoncheva Yuliya N., Yun Je-Yeon, Zanetti Marcus V., Zhou Fengfeng, Ziegler Georg C., Zierhut Kathrin C., Zwiers Marcel P., Thompson Paul M., Stein Dan J., Buitelaar Jan, Franke Barbara, van den Heuvel Odile A.
ISSN
0002-953X
1535-7228
Publication state
Published
Issued date
01/09/2020
Volume
177
Number
9
Pages
834-843
Language
english
Abstract
Objective: Attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these disorders using structural brain imaging data from ENIGMA consortium data.
Methods: Structural T1-weighted whole-brain MRI data from healthy control subjects (N=5,827) and from patients with ADHD (N=2,271), ASD (N=1,777), and OCD (N=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols. The authors examined subcortical volume, cortical thickness, and cortical surface area differences within a mega-analytical framework, pooling measures extracted from each cohort. Analyses were performed separately for children, adolescents, and adults, using linear mixed-effects models adjusting for age, sex, and site (and intracranial volume for subcortical and surface area measures).
Results: No shared differences were found among all three disorders, and shared differences between any two disorders did not survive correction for multiple comparisons. Children with ADHD compared with those with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children and adolescents with ADHD also had smaller intracranial volume than control subjects and those with OCD or ASD. Adults with ASD showed thicker frontal cortices compared with adult control subjects and other clinical groups. No OCD-specific differences were observed across different age groups and surface area differences among all disorders in childhood and adulthood.
Conclusions: The study findings suggest robust but subtle differences across different age groups among ADHD, ASD, and OCD. ADHD-specific intracranial volume and hippocampal differences in children and adolescents, and ASD-specific cortical thickness differences in the frontal cortex in adults, support previous work emphasizing structural brain differences in these disorders.
Keywords: Attention Deficit Hyperactivity Disorder; Autism Spectrum Disorder; ENIGMA; Obsessive-Compulsive Disorder; Structural MRI.
Keywords
Psychiatry and Mental health
OAI-PMH
oai:serval.unil.ch:BIB_1874591F7867
DOI
10.1176/appi.ajp.2020.19030331
Pubmed
32539527
Web of science
000564923300012
Create date
29/01/2021 15:51
Last modification date
30/01/2021 6:26
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