PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.

Détails

ID Serval
serval:BIB_185C03FE1024
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.
Périodique
Journal of Clinical Investigation
Auteur(s)
Iglesias J., Barg S., Vallois D., Lahiri S., Roger C., Yessoufou A., Pradevand S., McDonald A., Bonal C., Reimann F., Gribble F., Debril M.B., Metzger D., Chambon P., Herrera P., Rutter G.A., Prentki M., Thorens B., Wahli W.
ISSN
1558-8238 (Electronic)
ISSN-L
0021-9738
Statut éditorial
Publié
Date de publication
2012
Volume
122
Numéro
11
Pages
4105-4117
Langue
anglais
Résumé
PPARβ/δ protects against obesity by reducing dyslipidemia and insulin resistance via effects in muscle, adipose tissue, and liver. However, its function in pancreas remains ill defined. To gain insight into its hypothesized role in β cell function, we specifically deleted Pparb/d in the epithelial compartment of the mouse pancreas. Mutant animals presented increased numbers of islets and, more importantly, enhanced insulin secretion, causing hyperinsulinemia. Gene expression profiling of pancreatic β cells indicated a broad repressive function of PPARβ/δ affecting the vesicular and granular compartment as well as the actin cytoskeleton. Analyses of insulin release from isolated PPARβ/δ-deficient islets revealed an accelerated second phase of glucose-stimulated insulin secretion. These effects in PPARβ/δ-deficient islets correlated with increased filamentous actin (F-actin) disassembly and an elevation in protein kinase D activity that altered Golgi organization. Taken together, these results provide evidence for a repressive role for PPARβ/δ in β cell mass and insulin exocytosis, and shed a new light on PPARβ/δ metabolic action.
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/12/2012 18:39
Dernière modification de la notice
20/08/2019 12:48
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