Closed-loop Neuropharmacology for Epilepsy: Distant Dream or Future Reality?

Détails

Ressource 1Télécharger: Closed loop neuropharmacology for epilepsy V 2 1 with red JN_MP.pdf (692.14 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
ID Serval
serval:BIB_185B655D5EFA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Closed-loop Neuropharmacology for Epilepsy: Distant Dream or Future Reality?
Périodique
Current neuropharmacology
Auteur(s)
Aicua-Rapun I., André P., Novy J.
ISSN
1875-6190 (Electronic)
ISSN-L
1570-159X
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
17
Numéro
5
Pages
447-458
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Epilepsy is considered the most frequent severe neurological condition but most patients treated with medication become seizure free. The management of treatment, however, is highly empirical, mainly relying on observation. A closed-loop therapy for epilepsy would be very valuable for more efficient treatment regimens. Here we discuss monitoring treatment (therapeutic drug monitoring) and the potential developments in this field, as well as providing a review of potential biomarkers that could be used to monitor the disease activity. Finally, we consider the pharmacogenetic input in epilepsy treatment.
Mots-clé
Anticonvulsants/pharmacology, Anticonvulsants/therapeutic use, Biomarkers/metabolism, Cytokines/metabolism, Drug Monitoring/methods, Epilepsy/drug therapy, Epilepsy/genetics, Epilepsy/metabolism, Hormones/metabolism, Humans, Neuropharmacology, Pharmacogenetics, Randomized Controlled Trials as Topic, Biomarkers in epilepsy, cytokines, genetic factors, hormones, pharmacogenetics, refractory epilepsy, therapeutic drug monitoring.
Pubmed
Web of science
Création de la notice
15/03/2018 19:07
Dernière modification de la notice
13/09/2019 6:08
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