Ovarian cancer chemokines may not be a significant barrier during whole tumor antigen dendritic-cell vaccine and adoptive T-cell immunotherapy.
Details
Serval ID
serval:BIB_1852FDBECBFC
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Ovarian cancer chemokines may not be a significant barrier during whole tumor antigen dendritic-cell vaccine and adoptive T-cell immunotherapy.
Journal
Oncoimmunology
ISSN
2162-4011 (Print)
ISSN-L
2162-4011
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
5
Number
5
Pages
e1062210
Language
english
Abstract
Tumor barriers preventing T-cell homing and engraftment should be neutralized during cancer immunotherapy. We recently discovered that ovarian cancer expresses quasi-universal chemokines that can support T-cell homing. Furthermore, T cells elicited by whole tumor antigen dendritic-cell vaccines express cognate chemokine receptors which are upregulated by CD3/CD28 costimulation.
Pubmed
Web of science
Create date
05/08/2016 16:46
Last modification date
20/08/2019 12:48
Usage data
