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La maladie liée aux IgG4: une cause possible d'ictère obstructif [IgG4-related disease: a possible cause of obstructive jaundice].
Revue Médicale Suisse
Immunoglobulin G4 related disease (IgG4-RD) has been recognized since early 2000s as an entity comprising a set of inflammatory diseases with common histopathological features. The disease may affect almost all organs and tissues, and often occurs in a subacute fashion in males over 50 years as a mass or diffuse enlargement of affected organs. The histopathological appearance is characterized by a lymphoplasmacytic infiltration with predominantly IgG4-positive plasma cells and progressive fibrosis. Its clinical and radiological features can make the distinction with a malignancy difficult. The disease responds well to systemic glucocorticoids however with a high rate of recurrence after treatment discontinuation.
Aged, Autoimmune Diseases/complications, Autoimmune Diseases/drug therapy, Female, Glucocorticoids/therapeutic use, Humans, Immunoglobulin G/immunology, Jaundice, Obstructive/drug therapy, Jaundice, Obstructive/etiology, Male, Middle Aged, Recurrence
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