Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Vincristine and intestinal pseudo-obstruction in children: report of 5 cases, literature review, and suggested management.
Journal of Pediatric Hematology/Oncology
Publication types: Case Reports ; Journal Article
Summary: Intestinal pseudo-obstruction is a rare complication resulting from a variety of disorders. Symptoms include abdominal pain, nausea, vomiting, diarrhea, constipation, and malnutrition. Vincristine-related pseudo-obstruction has been reported in the literature, but its description in children and recommendations for management are lacking. A review of the literature revealed 21 reported pediatric cases of vincristine-related pseudo-obstruction. Most have, however, been attributed to a drug interaction with itraconazole, accidental vincristine overdose, or liver failure. Potential genetic causes are rarely addressed. We present here 5 cases of pseudo-obstruction related to vincristine without any identifiable predisposing factors, and a suggested algorithm for management
Adolescent, Algorithms, Antineoplastic Agents, Phytogenic/adverse effects, Child, Child, Preschool, Female, Hodgkin Disease/drug therapy, Humans, Intestinal Pseudo-Obstruction/chemically induced, Intestinal Pseudo-Obstruction/therapy, Kidney Neoplasms/drug therapy, Male, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Survival Rate, Treatment Outcome, Vincristine/adverse effects, Wilms Tumor/drug therapy
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