Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
A research agenda for malaria eradication: vaccines.
malERA Consultative Group on Vaccines
Abdulla S., Agre P., Alonso PL., Arevalo-Herrera M., Bassat Q., Binka F., Chitnis C., Corradin G., Cowman A., Culpepper J., del Portillo H., Dinglasan R., Duffy P., Gargallo D., Greenwood B., Guinovart C., Hall BF., Herrera£££Sócrates£££ S. , Hoffman S., Lanzavecchia A., Leroy O., Levine MM., Loucq C., Mendis K., Milman J., Moorthy V., Pleuschke G., Plowe CV., Reed S., Sauerwein R., Saul A., Schofield L., Sinden R., Stubbs J., Villafana T., Wirth D., Yadav P., Ballou R., Brown G., Birkett A., Brandt W., Brooks A., Carter T., Golden A., Lee C., Nunes J., Puijalon O., Raphael T., Richards H., Warren C., Woods C.
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Publication Status: epublish
Vaccines could be a crucial component of efforts to eradicate malaria. Current attempts to develop malaria vaccines are primarily focused on Plasmodium falciparum and are directed towards reducing morbidity and mortality. Continued support for these efforts is essential, but if malaria vaccines are to be used as part of a repertoire of tools for elimination or eradication of malaria, they will need to have an impact on malaria transmission. We introduce the concept of "vaccines that interrupt malaria transmission" (VIMT), which includes not only "classical" transmission-blocking vaccines that target the sexual and mosquito stages but also pre-erythrocytic and asexual stage vaccines that have an effect on transmission. VIMT may also include vaccines that target the vector to disrupt parasite development in the mosquito. Importantly, if eradication is to be achieved, malaria vaccine development efforts will need to target other malaria parasite species, especially Plasmodium vivax, where novel therapeutic vaccines against hypnozoites or preventive vaccines with effect against multiple stages could have enormous impact. A target product profile (TPP) for VIMT is proposed and a research agenda to address current knowledge gaps and develop tools necessary for design and development of VIMT is presented.
Animals, Anopheles/parasitology, Clinical Trials as Topic, Decision Making, Disease Outbreaks/prevention & control, Host-Parasite Interactions, Humans, Insect Vectors/parasitology, Licensure, Malaria/prevention & control, Malaria/transmission, Malaria Vaccines, Malaria, Falciparum/prevention & control, Malaria, Falciparum/transmission, Malaria, Vivax/prevention & control, Malaria, Vivax/transmission, Parasitemia/parasitology, Parasitemia/prevention & control, Plasmodium falciparum/immunology, Plasmodium falciparum/physiology, Plasmodium vivax/growth & development, Plasmodium vivax/immunology, Reproduction, Research, Species Specificity, Translational Medical Research
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