The distribution of congenital anomalies within the VACTERL association among tumor necrosis factor antagonist-exposed pregnancies is similar to the general population.
Details
Serval ID
serval:BIB_17B42371DDDF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The distribution of congenital anomalies within the VACTERL association among tumor necrosis factor antagonist-exposed pregnancies is similar to the general population.
Journal
Journal of Rheumatology
Working group(s)
EUROCAT Working Group
ISSN
0315-162X (Print)
ISSN-L
0315-162X
Publication state
Published
Issued date
2011
Volume
38
Number
9
Pages
1871-1874
Language
english
Notes
Publication types: Comparative Study ; Journal ArticlePublication Status: ppublish. MC Addor fait partie de EUROCAT Working Group.
Abstract
OBJECTIVE: To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-α (TNF-α) antagonist and the general population.
METHODS: Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database.
RESULTS: Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-α antagonist exposure, so comparison of proportions was imprecise. Only the category "limb abnormalities" showed a significantly higher proportion in the general population.
CONCLUSION: The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-α antagonists could not be confirmed using a population-based congenital anomaly database.
METHODS: Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database.
RESULTS: Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-α antagonist exposure, so comparison of proportions was imprecise. Only the category "limb abnormalities" showed a significantly higher proportion in the general population.
CONCLUSION: The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-α antagonists could not be confirmed using a population-based congenital anomaly database.
Keywords
Abnormalities, Drug-Induced/classification, Abnormalities, Drug-Induced/epidemiology, Adult, Anal Canal/abnormalities, Cohort Studies, Databases, Factual, Esophagus/abnormalities, Europe/epidemiology, Female, Heart Defects, Congenital/chemically induced, Heart Defects, Congenital/epidemiology, Humans, Immunologic Factors/adverse effects, Infant, Newborn, Kidney/abnormalities, Limb Deformities, Congenital/chemically induced, Limb Deformities, Congenital/epidemiology, Pregnancy, Prenatal Exposure Delayed Effects, Spine/abnormalities, Trachea/abnormalities, Tumor Necrosis Factor-alpha/antagonists & inhibitors, Tumor Necrosis Factor-alpha/physiology
Pubmed
Web of science
Create date
14/02/2013 10:46
Last modification date
20/08/2019 13:47
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