Can the trabecular bone score be considered as a major clinical risk factor of osteoporotic fractures? A meta-like analysis.
Details
Serval ID
serval:BIB_17B0BF9536B1
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Can the trabecular bone score be considered as a major clinical risk factor of osteoporotic fractures? A meta-like analysis.
Title of the conference
Interdisziplinärer Fachkongress OSTEOLOGIE des Dachverbandes Osteologie (DVO)
Address
Basel, Schweiz, 29.-31. März 2012
ISBN
1019-1291
Publication state
Published
Issued date
2012
Volume
21
Series
Osteologie
Pages
A34
Language
english
Abstract
To have an added value over BMD, a CRF of osteoporotic fracture must be
predictable of the fracture, independent of BMD, reversible and quantifiable.
Many major recognized CRF exist. Out of these factors many of them are indirect
factor of bone quality. TBS predicts fracture independently of BMD as
demonstrated from previous studies. The aim of the study is to verify if TBS
can be considered as a major CRF of osteoporotic fracture.
Existing validated datasets of Caucasian women were analyzed. These datasets
stem from different studies performed by the authors of this report or provided
to our group. However, the level of evidence of these studies will vary. Thus,
the different datasets were weighted differently according to their design.
This meta-like analysis involves more than 32000 women (≥50years) with 2000
osteoporotic fractures from two prospective studies (OFELY&MANITOBA)
and 7 cross-sectional studies. Weighted relative risk (RR) for TBS was expressed
for each decrease of one standard deviation as well as per tertile difference
(TBS=1.300 and 1.200) and compared with those obtained for the major
CRF included in FRAX®.
Overall TBS RR obtained (adjusted for age) was 1.79 [95%CI-1.37-2.37]. For
all women combined, RR for fracture for the lowest compared with the middle
TBS tertile was 1.55[1.46-1.68] and for the lowest compared with the highest
TBS tertile was 2.8[2.70-3.00].
TBS is comparable to most of the major CRF and thus could be used as one of
them. Further studies have to be conducted to confirm these first findings.
predictable of the fracture, independent of BMD, reversible and quantifiable.
Many major recognized CRF exist. Out of these factors many of them are indirect
factor of bone quality. TBS predicts fracture independently of BMD as
demonstrated from previous studies. The aim of the study is to verify if TBS
can be considered as a major CRF of osteoporotic fracture.
Existing validated datasets of Caucasian women were analyzed. These datasets
stem from different studies performed by the authors of this report or provided
to our group. However, the level of evidence of these studies will vary. Thus,
the different datasets were weighted differently according to their design.
This meta-like analysis involves more than 32000 women (≥50years) with 2000
osteoporotic fractures from two prospective studies (OFELY&MANITOBA)
and 7 cross-sectional studies. Weighted relative risk (RR) for TBS was expressed
for each decrease of one standard deviation as well as per tertile difference
(TBS=1.300 and 1.200) and compared with those obtained for the major
CRF included in FRAX®.
Overall TBS RR obtained (adjusted for age) was 1.79 [95%CI-1.37-2.37]. For
all women combined, RR for fracture for the lowest compared with the middle
TBS tertile was 1.55[1.46-1.68] and for the lowest compared with the highest
TBS tertile was 2.8[2.70-3.00].
TBS is comparable to most of the major CRF and thus could be used as one of
them. Further studies have to be conducted to confirm these first findings.
Create date
24/01/2013 12:10
Last modification date
20/08/2019 13:47
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