Article: article from journal or magazin.
Immunogenicity of influenza vaccine (1993-94 winter season) in HIV-seropositive and -seronegative ex-intravenous drug users.
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
The humoral response (haemagglutination inhibiting antibodies) to trivalent split influenza vaccine for the 1993-94 winter season (A/Beijing/32/92 (H3N2), A/Singapore/6/86 (H1N1) and B/Panama/45/90) was evaluated in a group of young HIV-seropositive ex-intravenous heroin users and compared with responses measured in HIV-seronegative individuals with a similar history. HIV-negative volunteers showed an overall positive response suggesting that previous heroin use did not influence their humoral response to influenza vaccine. Comparable results were obtained in HIV-positive subjects with CD4+ lymphocyte counts > 500 microliters-1, whereas impaired reactivity was found in HIV-positive volunteers with CD4+ counts < 500 microliters-1. Booster vaccination did not increase antibody levels in any of the groups studied, although the data did not exclude a positive influence of a second vaccine dose on persistence of antibody at 120 days after the first dose. No significant changes were observed in p24 antigenemia levels in HIV-positive individuals after vaccination.
Adult, Antibodies, Viral/biosynthesis, CD4 Lymphocyte Count, Female, HIV Antibodies/blood, HIV Core Protein p24/blood, HIV Infections/complications, HIV Infections/immunology, HIV Seronegativity/immunology, Humans, Immunization, Secondary, Influenza Vaccines/immunology, Male, Middle Aged, Substance Abuse, Intravenous/complications
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