Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_17206
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells.
Périodique
The Journal of Experimental Medicine
Auteur(s)
Tenan M., Fulci G., Albertoni M., Diserens A.C., Hamou M.F., El Atifi-Borel M., Feige J.J., Pepper M.S., Van Meir E.G.
ISSN
0022-1007
Statut éditorial
Publié
Date de publication
2000
Volume
191
Numéro
10
Pages
1789-1798
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Résumé
Angiogenesis, the sprouting of new capillaries from preexisting blood vessels, results from a disruption of the balance between stimulatory and inhibitory factors. Here, we show that anoxia reduces expression of thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, in glioblastoma cells. This suggests that reduced oxygen tension can promote angiogenesis not only by stimulating the production of inducers, such as vascular endothelial growth factor, but also by reducing the production of inhibitors. This downregulation may significantly contribute to glioblastoma development, since we show that an increase in TSP-1 expression is sufficient to strongly suppress glioblastoma cell tumorigenicity in vivo.
Mots-clé
Animals, Anoxia/genetics, Anoxia/physiopathology, Base Sequence, DNA Primers/genetics, Down-Regulation, Genes, p53, Glioblastoma/blood supply, Glioblastoma/genetics, Humans, Male, Mice, Mice, Nude, Neoplasm Transplantation, Neovascularization, Pathologic/genetics, RNA, Messenger/genetics, RNA, Messenger/metabolism, RNA, Neoplasm/genetics, RNA, Neoplasm/metabolism, Thrombospondin 1/biosynthesis, Thrombospondin 1/genetics, Transplantation, Heterologous, Tumor Cells, Cultured
Pubmed
Web of science
Création de la notice
19/11/2007 13:10
Dernière modification de la notice
20/08/2019 13:46
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