Prenatal Risk Factors and Outcomes in Gastroschisis: A Meta-Analysis.

Détails

ID Serval
serval:BIB_170FFF6327F0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prenatal Risk Factors and Outcomes in Gastroschisis: A Meta-Analysis.
Périodique
Pediatrics
Auteur(s)
D'Antonio F., Virgone C., Rizzo G., Khalil A., Baud D., Cohen-Overbeek T.E., Kuleva M., Salomon L.J., Flacco M.E., Manzoli L., Giuliani S.
ISSN
1098-4275 (Electronic)
ISSN-L
0031-4005
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
136
Numéro
1
Pages
e159-e169
Langue
anglais
Notes
Publication types: Journal Article ; Review ; WOS : article
Résumé
BACKGROUND AND OBJECTIVE: Gastroschisis is a congenital anomaly with increasing incidence, easy prenatal diagnosis and extremely variable postnatal outcomes. Our objective was to systematically review the evidence regarding the association between prenatal ultrasound signs (intraabdominal bowel dilatation [IABD], extraabdominal bowel dilatation, gastric dilatation [GD], bowel wall thickness, polyhydramnios, and small for gestational age) and perinatal outcomes in gastroschisis (bowel atresia, intra uterine death, neonatal death, time to full enteral feeding, length of total parenteral nutrition and length of in hospital stay).
METHODS: Medline, Embase, and Cochrane databases were searched electronically. Studies exploring the association between antenatal ultrasound signs and outcomes in gastroschisis were considered suitable for inclusion. Two reviewers independently extracted relevant data regarding study characteristics and pregnancy outcome. All meta-analyses were computed using individual data random-effect logistic regression, with single study as the cluster unit.
RESULTS: Twenty-six studies, including 2023 fetuses, were included. We found significant positive associations between IABD and bowel atresia (odds ratio [OR]: 5.48, 95% confidence interval [CI] 3.1-9.8), polyhydramnios and bowel atresia (OR: 3.76, 95% CI 1.7-8.3), and GD and neonatal death (OR: 5.58, 95% CI 1.3-24.1). No other ultrasound sign was significantly related to any other outcome.
CONCLUSIONS: IABD, polyhydramnios, and GD can be used to an extent to identify a subgroup of neonates with a prenatal diagnosis of gastroschisis at higher risk to develop postnatal complications. Data are still inconclusive on the predictive ability of several signs combined, and large prospective studies are needed to improve the quality of prenatal counseling and the neonatal care for this condition.
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/08/2015 8:50
Dernière modification de la notice
20/08/2019 12:46
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