Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study.

Medas, F.; Dobrinja, C.; Al-Suhaimi, E.A.; Altmeier, J.; Anajar, S.; Arikan, A.E.; Azaryan, I.; Bains, L.; Basili, G.; Bolukbasi, H.; Bononi, M.; Borumandi, F.; Bozan, M.B.; Brenta, G.; Brunaud, L.; Brunner, M.; Buemi, A.; Canu, G.L.; Cappellacci, F.; Cartwright, S.B.; Castells Fusté, I.; Cavalheiro, B.; Cavallaro, G.; Chala, A.; Chan, SYB; Chaplin, J.; Cheema, M.S.; Chiapponi, C.; Chiofalo, M.G.; Chrysos, E.; D'Amore, A.; de Cillia, M.; De Crea, C.; de Manzini, N.; de Matos, L.L.; De Pasquale, L.; Del Rio, P.; Demarchi, M.S.; Dhiwakar, M.; Donatini, G.; Dora, J.M.; D'Orazi, V.; Doulatram Gamgaram, V.K.; Eismontas, V.; Kabiri, E.H.; El Malki, H.O.; Elzahaby, I.; Enciu, O.; Eskander, A.; Feroci, F.; Figueroa-Bohorquez, D.; Filis, D.; François, G.; Frías-Fernández, P.; Gamboa-Dominguez, A.; Genc, V.; Giordano, D.; Gómez-Pedraza, A.; Graceffa, G.; Griffin, J.; Guerreiro, S.C.; Gupta, K.; Gupta, K.K.; Gurrado, A.; Hajiioannou, J.; Hakala, T.; Harahap, W.A.; Hargitai, L.; Hartl, D.; Hellmann, A.; Hlozek, J.; Hoang, V.T.; Iacobone, M.; Innaro, N.; Ioannidis, O.; Jang, JHI; Xavier-Junior, J.C.; Jovanovic, M.; Kaderli, R.M.; Kakamad, F.; Kaliszewski, K.; Karamanliev, M.; Katoh, H.; Košec, A.; Kovacevic, B.; Kowalski, L.P.; Králik, R.; Yadav, S.K.; Kumorová, A.; Lampridis, S.; Lasithiotakis, K.; Leclere, J.C.; Leong, EKF; Leow, M.K.; Lim, J.Y.; Lino-Silva, L.S.; Liu, SYW; Llorach, N.P.; Lombardi, C.P.; López-Gómez, J.; Lori, E.; Quintanilla-Dieck, L.; Lucchini, R.; Madani, A.; Manatakis, D.; Markovic, I.; Materazzi, G.; Mazeh, H.; Mercante, G.; Meyer-Rochow, G.Y.; Mihaljevic, O.; Miller, J.A.; Minuto, M.; Monacelli, M.; Mulita, F.; Mullineris, B.; Muñoz-de-Nova, J.L.; Muradás Girardi, F.; Nader, S.; Napadon, T.; Nastos, C.; Offi, C.; Ronen, O.; Oragano, L.; Orois, A.; Pan, Y.; Panagiotidis, E.; Panchangam, R.B.; Papavramidis, T.; Parida, P.K.; Paspala, A.; Pérez, Ò.V.; Petrovic, S.; Raffaelli, M.; Ramacciotti, C.F.; Ratia Gimenez, T.; Rivo Vázquez, Á.; Roh, J.L.; Rossi, L.; Sanabria, A.; Santeerapharp, A.; Semenov, A.; Seneviratne, S.; Serdar, A.; Sheahan, P.; Sheppard, S.C.; Slotcavage, R.L.; Smaxwil, C.; Kim, S.Y.; Sorrenti, S.; Spartalis, E.; Sriphrapradang, C.; Testini, M.; Turk, Y.; Tzikos, G.; Vabalayte, K.; Vargas-Osorio, K.; Vázquez Rentería, R.S.; Velázquez-Fernández, D.; Vithana, SMP; Yücel, L.; Yulian, E.D.; Zahradnikova, P.; Zarogoulidis, P.; Ziablitskaia, E.; Zolotoukho, A.; Calò, P.G.

doi:10.1016/S2213-8587(23)00094-3

Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study.

Details

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Serval ID

serval:BIB_16DF3DAFEEA5

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study.

Journal

The lancet. Diabetes & endocrinology

Author(s)

Medas F., Dobrinja C., Al-Suhaimi E.A., Altmeier J., Anajar S., Arikan A.E., Azaryan I., Bains L., Basili G., Bolukbasi H., Bononi M., Borumandi F., Bozan M.B., Brenta G., Brunaud L., Brunner M., Buemi A., Canu G.L., Cappellacci F., Cartwright S.B., Castells Fusté I., Cavalheiro B., Cavallaro G., Chala A., Chan SYB, Chaplin J., Cheema M.S., Chiapponi C., Chiofalo M.G., Chrysos E., D'Amore A., de Cillia M., De Crea C., de Manzini N., de Matos L.L., De Pasquale L., Del Rio P., Demarchi M.S., Dhiwakar M., Donatini G., Dora J.M., D'Orazi V., Doulatram Gamgaram V.K., Eismontas V., Kabiri E.H., El Malki H.O., Elzahaby I., Enciu O., Eskander A., Feroci F., Figueroa-Bohorquez D., Filis D., François G., Frías-Fernández P., Gamboa-Dominguez A., Genc V., Giordano D., Gómez-Pedraza A., Graceffa G., Griffin J., Guerreiro S.C., Gupta K., Gupta K.K., Gurrado A., Hajiioannou J., Hakala T., Harahap W.A., Hargitai L., Hartl D., Hellmann A., Hlozek J., Hoang V.T., Iacobone M., Innaro N., Ioannidis O., Jang JHI, Xavier-Junior J.C., Jovanovic M., Kaderli R.M., Kakamad F., Kaliszewski K., Karamanliev M., Katoh H., Košec A., Kovacevic B., Kowalski L.P., Králik R., Yadav S.K., Kumorová A., Lampridis S., Lasithiotakis K., Leclere J.C., Leong EKF, Leow M.K., Lim J.Y., Lino-Silva L.S., Liu SYW, Llorach N.P., Lombardi C.P., López-Gómez J., Lori E., Quintanilla-Dieck L., Lucchini R., Madani A., Manatakis D., Markovic I., Materazzi G., Mazeh H., Mercante G., Meyer-Rochow G.Y., Mihaljevic O., Miller J.A., Minuto M., Monacelli M., Mulita F., Mullineris B., Muñoz-de-Nova J.L., Muradás Girardi F., Nader S., Napadon T., Nastos C., Offi C., Ronen O., Oragano L., Orois A., Pan Y., Panagiotidis E., Panchangam R.B., Papavramidis T., Parida P.K., Paspala A., Pérez Ò.V., Petrovic S., Raffaelli M., Ramacciotti C.F., Ratia Gimenez T., Rivo Vázquez Á., Roh J.L., Rossi L., Sanabria A., Santeerapharp A., Semenov A., Seneviratne S., Serdar A., Sheahan P., Sheppard S.C., Slotcavage R.L., Smaxwil C., Kim S.Y., Sorrenti S., Spartalis E., Sriphrapradang C., Testini M., Turk Y., Tzikos G., Vabalayte K., Vargas-Osorio K., Vázquez Rentería R.S., Velázquez-Fernández D., Vithana SMP, Yücel L., Yulian E.D., Zahradnikova P., Zarogoulidis P., Ziablitskaia E., Zolotoukho A., Calò P.G.

Working group(s)

THYCOVID Collaboration Group

Contributor(s)

Abdallah A., Abentroth A.L., Acheimastos V., Agunaoun M., Al Bisher H.M., Al Ghuzlan A., Alakus H., Alkan M., Almaraz Almaraz M.C., Amram K., Anesidis S., Anestiadou E., Angelucci D., Ansaldo G.L., Antonopoulou M.I., Arciniegas M., Armellin C., Arredondo Saldaña G., Astl J., Athanasakis E., Avenia S., Aydın H., Baba B., Babala J., Banús M.V., Barba-Valadez L.A., Barcons S.V., Battafarano F., Bayat A., Bella R., Benariba F., Bernardi S., Bignami E.G., Bitenc M., Bitsianis S., Bolaños de la Torre J., Bonati E., Bonetti T., Borges F.A., Bouchagier K., Boudina M., Bourial A., Breuskin I., Brock P., Bruns C., Burlacu M.C., Burton T., Buta M., Buzanakov D., Caliseo C., Callanan D., Calu V., Cameselle-Teijeiro J.M., Camilo-Junior D.J., Canberk S., Candalise V., Candanedo-Gonzalez F., Carrillo Lizarazo L.J., Carvalho G.B., Casallas D., Casolino C., Castellani L., Castillo Morales C., Chambon G., Chatzipavlidou V., Chernikov R., Chorti A., Chow T., Chrisoulidou A., Chrysos E., Conrado-Neto S., Cordova García D., Corigliano A., Crocco A., Cuesta A., Čukman M., Curto L.S., Damilano R.A., D'Anna R., De M., De Virgilio A., Dellaportas D., Demarquet L., Devresse A., Di Meo G., Diaz Pedrero R., Dimitrov D., Dmitry Z., Domínguez Garijo P., Dulgeroglu O., Dural A.C., Eksi A., El Hammoumi M., El Kaoui H., Eleni G., Elliyanti A., Ersöz Ş., Escobar-Jiménez M., Fedorova L., Feeley L., Fernández Rodríguez E., Ferreli F., Filoia A., Fingeret A., Francescato A., Gaino F., Galiandro F., Gallegos-Hernández J.F., Garas G., García Lorenzo F., García-Chávez J.P., Gaudiello M., Gay S., Gerasimos S., Gerek M., Gervasi R., Giordano A., Gjeloshi B., Gocký L., Golubinskaya E., González Romero S., González-Mínguez C., Goran M., Gosman A., Granados Garcia M., Greco E., Grünbart M., Grützmann R., Guerlain J., Guirao X.G., Guzey D., Hajjij A., Hamdy O., Hameed M.S., Hauth L.A., Hernández-Acevedo J.D., Hernandez-Carrillo J.F., Hevilla Sánchez F., Hoi H., Hongkwon K., Hu Zhu R., Huang E., Hyeung Kyoo K., Ignjatovic V., Ioannidis A., Iossa A., Işık A., James D., Jung Hoon L., Kara H., Karajovic J., Kartini D., Khambri D., Kholová I., Kisiel M., Knežević M., Koh Y.Q., Konca C., Kosmidis C., Kotsovolis G., Kowalski L.P., Kralik R., Kuczma P., Kuravi B.G., Kurnia A., Kyriaki V., Lai C.M., Lallemant B., Lardhi A.A., Leboulleux S., Lee J.W., Lelli G., Leutner M., Lim M.Y., Lim C.M., Llanos A., Lo X., Loderer T., López-Corrales M.A., Ludwig M., Magnabosco F.F., Maheo C., Maia A.L., Makay O., Maksimova P., Mallick S., Mallouk C., Mamani Z., Mandal S., Manyalich Blasi M., Marincola G., Marulanda M., Mavromati M., Mayilvaganan S., Metso S., Micalizzi A., Michalopoulos A., Min-Su K., Miron A., Mishra A.K., Misso C., Mittermair C., Morosán Allo Y., Mourad M., Moysidis M., Nabhan F., Nasiri R., Nastos C., Ngiam K.Y., Nomine-Criqui C., Ntziovara A.M., Nuño Vázquez-Garza J.M., Nutautiene V., Obtulovičová K., O'Keeffe L., Okudur N.O., Ossola P., Ovejero Merino E., Ozdemir M., Pangonis A., Panigoro S.S., Panuzi A., Papaconstantinou D., Pardo Matamoros N., Paschou S., Pasculli A., Paterakis K., Peiris K., Pennestrì F., Peppa M., Perdikaris P., Perdikaris I., Pérez-Soto R.H., Piana S., Piccoli M., Pietrasanta D., Placentino G., Pliakos I., Polistena A., Pongtippan A., Potard G., Quinn V., Rahul P., Ramos T., Rankin A., Ratnayake P., Reuto-Castillo J., Ridolfo A., Rios-Valencia J., Riss P., Rival E., Rivillas J., Roi D., Rollo E.M., Romanchishen A., Romito M., Rotnagl J., Rovcanin B., Russo G., Sabol M., Saki S., Saleh S., Salih A., Saltiki A., Salvador-Camarmo G., Samal D.K., Sánchez-Flores S., Sapalidis K., Sarin D., Sarin H., Savkovic N., Scheffel R.S., Scheinpflug A.L., Scheuba C., Scheyer N., Schmidt M., Senashova O., Serafini E., Serrano Arévalo M.L., Shank J., Shindo M.L., Shoshkova M., Shvan M., Sičák M., Silva T.G., Simó Guerrero O., Skuletic V., Slijepcevic N., Slovic Z., Soares P., Somova A., Soto S., Spiezia S., Stankovic V., Stephenson K.J., Straub E., Summa M., Surani S., Syed A.A., Symeonidis S., Taciak A., Tarallo M., Tarle A., Tasis N., Tausanovic K., Tchabashvili L., Thierry M., Tokarczyk U., Toma E.A., Topuz S., Torresan F., Uras C., Vaccaro C., Valdés de Anca Á., Valentini M., Varaldo E., Vartanian J.G., Verras G.I., Vithanage A., Wijayalathge H., Wiriyaamornchai P., Wong Y., Wongwattana P., Xenaki S., Xie S., Xu M., Yang W., Yilmaz S., Yılmaz Y.F., Yotsov T., Zahid M.T., Zielke A.

ISSN

2213-8595 (Electronic)

ISSN-L

2213-8587

Publication state

Published

Issued date

06/2023

Peer-reviewed

Oui

Volume

Number

Pages

402-413

Language

english

Notes

Publication types: Multicenter Study ; Journal Article
Publication Status: ppublish

Abstract

Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours.
In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186.
Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1·4 [IQR 0·6-3·4]) compared with the prepandemic phase (2·0 [0·9-3·7]; p<0·0001) and pandemic decrease phase (2·3 [1·0-5·0]; p<0·0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69·0%] of 3704 vs 1515 [71·5%] of 2119; OR 1·1 [95% CI 1·0-1·3]; p=0·042), lymph node metastases (343 [9·3%] vs 264 [12·5%]; OR 1·4 [1·2-1·7]; p=0·0001), and tumours at high risk of structural disease recurrence (203 [5·7%] of 3584 vs 155 [7·7%] of 2006; OR 1·4 [1·1-1·7]; p=0·0039).
Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation.
None.

Keywords

Humans, Male, Female, Thyroid Nodule/epidemiology, Thyroid Nodule/surgery, Thyroid Nodule/diagnosis, Cross-Sectional Studies, Pandemics, Retrospective Studies, Lymphatic Metastasis, COVID-19/epidemiology, Thyroid Neoplasms/epidemiology, Thyroid Neoplasms/surgery, Thyroid Neoplasms/pathology

URN

urn:nbn:ch:serval-BIB_16DF3DAFEEA54

OAI-PMH

oai:serval.unil.ch:BIB_16DF3DAFEEA5

DOI

10.1016/S2213-8587(23)00094-3

Pubmed

37127041

Web of science

001062120200001

Create date

08/05/2023 11:34