Interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in pregnant C57BL/6 mice infected with L. major at different gestational periods.

Détails

ID Serval
serval:BIB_16B78571D061
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in pregnant C57BL/6 mice infected with L. major at different gestational periods.
Périodique
West African Journal of Medicine
Auteur(s)
Arinola O.G., Louis J., Tacchini-Cottier F., Aseffa A., Salimonu L.S.
ISSN
0189-160X (Print)
ISSN-L
0189-160X
Statut éditorial
Publié
Date de publication
2004
Volume
23
Numéro
3
Pages
202-207
Langue
anglais
Résumé
BACKGROUND AND OBJECTIVE: To assess if gestational factors affect the resistance of C57BL/6 mice to L major infection, this study determined the levels of IL-4 and IFN-gamma in popliteal lymph node cells of pregnant C57BL/6 mice infected with L. major at 16 hours, 5 days-, 10 days- and 15 days- post plug by PCR, ELISA and BIOASSAY.
DESIGN/SETTING: Experimental.
RESULTS: Infected pregnant C57BL/6 mice developed larger cutaneous footpad lesions compared with non-pregnant C57BL/6 mice (that showed signs of resolution 7-10 weeks after infection). But, the lesions in infected pregnant C57BL/6 mice and infected non-pregnant C57BL/6 mice were not as large as in susceptible BALB/c mice. The mean litter weight was also reduced in pregnant infected C57BL/6 mice particularly in the groups infected at later stages of pregnancy (day 10- and day 15-post plug). The levels of both IL-4 and IFN-gamma increased with gestation in pregnant infected C57BL/6 mice compared with pregnant non-infected group, while only IL-4 was raised in pregnant infected mice compared with infected non pregnant mice.
CONCLUSIONS: It may be concluded that increased IL-4 in pregnant infected C57BL/6 mice caused the transient susceptibility to L major infection while reduced litter weight was associated with increased IFN-gamma. These effects were pronounced in C57BI/6 mice infected with L major in late pregnancy.
Mots-clé
Animals, Antigens, Protozoan/immunology, Female, Interferon-gamma/analysis, Interleukin-4/analysis, Leishmania major/isolation & purification, Leishmaniasis, Cutaneous/immunology, Mice, Mice, Inbred C57BL, Pregnancy
Pubmed
Création de la notice
24/01/2008 16:09
Dernière modification de la notice
20/08/2019 13:46
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