Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma.

Détails

Ressource 1Télécharger: PMID29644341.pdf (778.84 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_169B42791B55
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma.
Périodique
Journal of the Endocrine Society
Auteur(s)
Papadakis G.E., Tabotta F., Levotanec I., Gonzalez M., Prior J.O., La Rosa S., Sykiotis G.P.
ISSN
2472-1972 (Electronic)
ISSN-L
2472-1972
Statut éditorial
Publié
Date de publication
01/04/2018
Peer-reviewed
Oui
Volume
2
Numéro
4
Pages
386-390
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Technetium-99m methoxy isobutyl isonitrile ( <sup>99m</sup> Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on <sup>18</sup> F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2.0 g/mL). A sestamibi SPECT/CT performed because of concomitant primary hyperparathyroidism showed increased uptake by both the MTC and the pulmonary nodule, raising suspicion of MTC metastasis. Lung wedge resection biopsy revealed a sclerosing pneumocytoma (SPC), a rare benign pulmonary tumor not previously known to retain sestamibi. In contrast to classical knowledge that sestamibi uptake by tumors is associated with its retention by mitochondria, immunohistochemical analyses showed that the mitochondrial content of the patient's SPC was low. This case illustrates the behavior of SPC in sestamibi scintigraphy and indicates that SPC is a potential cancer mimicker in this setting.

Mots-clé
18F-FDG PET/CT, 99mTc-MIBI, medullary thyroid carcinoma, mitochondria, sclerosing pneumocytoma
Pubmed
Open Access
Oui
Création de la notice
17/04/2018 11:30
Dernière modification de la notice
20/08/2019 13:46
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