Article: article from journal or magazin.
In vitro metabolism of citalopram by monoamine oxidase B in human blood
DA - 20010306 IS - 0924-977X LA - eng PT - Journal Article RN - 0 (Antidepressive Agents) RN - 59729-33-8 (Citalopram) RN - EC 18.104.22.168 (Monoamine Oxidase) SB - IM Institution : Unite de Biochimie et Psychopharmacologie Clinique, Departement Universitaire de Psychiatrie Adulte, CH-1008 Prilly-Lausanne, Switzerland Mention de responsabiblité : Kosel,M.;Amey,M.;Aubert,A.C.;Baumann,P. SAPHIRID:48159
The metabolism of the antidepressant citalopram (CIT) by monoamine oxidase B (MAO-B) was studied in vitro. In incubations with blood of nine healthy volunteers R-(P=0.015) and S-(P=0.0034) CIT propionic acid (CITPROP) production was correlated with the number of platelets. S-CITPROP production was 5.6 times higher than R-CITPROP production and in incubations containing the MAO-B inhibitor deprenyl, racemic CITPROP production was diminished to 9.1%. To our knowledge, this is the first time that MAO-B activity in blood is shown with an antidepressant as substrate. As MAO is strongly expressed in human brain, this observation suggests that this enzymatic system may be implicated in drug metabolism in the CNS
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