The behavioral relevance of a modular organization in the lateral habenula.
Details
Serval ID
serval:BIB_160BC73DA01F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The behavioral relevance of a modular organization in the lateral habenula.
Journal
Neuron
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
21/08/2024
Peer-reviewed
Oui
Volume
112
Number
16
Pages
2669-2685
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Behavioral strategies for survival rely on the updates the brain continuously makes based on the surrounding environment. External stimuli-neutral, positive, and negative-relay core information to the brain, where a complex anatomical network rapidly organizes actions, including approach or escape, and regulates emotions. Human neuroimaging and physiology in nonhuman primates, rodents, and teleosts suggest a pivotal role of the lateral habenula in translating external information into survival behaviors. Here, we review the literature describing how discrete habenular modules-reflecting the molecular signatures, anatomical connectivity, and functional components-are recruited by environmental stimuli and cooperate to prompt specific behavioral outcomes. We argue that integration of these findings in the context of valence processing for reinforcing or discouraging behaviors is necessary, offering a compelling model to guide future work.
Keywords
Habenula/physiology, Animals, Humans, Neural Pathways/physiology, Nerve Net/physiology, Nerve Net/diagnostic imaging, Emotions/physiology, behavior, connectivity, function, habenula, molecular programs
Pubmed
Open Access
Yes
Create date
22/05/2024 17:18
Last modification date
27/08/2024 7:19