A standard calculation methodology for human doubly labeled water studies.

Speakman, J.R.; Yamada, Y.; Sagayama, H.; Berman, ESF; Ainslie, P.N.; Andersen, L.F.; Anderson, L.J.; Arab, L.; Baddou, I.; Bedu-Addo, K.; Blaak, E.E.; Blanc, S.; Bonomi, A.G.; Bouten, CVC; Bovet, P.; Buchowski, M.S.; Butte, N.F.; Camps, SGJA; Close, G.L.; Cooper, J.A.; Creasy, S.A.; Das, S.K.; Cooper, R.; Dugas, L.R.; Ebbeling, C.B.; Ekelund, U.; Entringer, S.; Forrester, T.; Fudge, B.W.; Goris, A.H.; Gurven, M.; Hambly, C.; El Hamdouchi, A.; Hoos, M.B.; Hu, S.; Joonas, N.; Joosen, A.M.; Katzmarzyk, P.; Kempen, K.P.; Kimura, M.; Kraus, W.E.; Kushner, R.F.; Lambert, E.V.; Leonard, W.R.; Lessan, N.; Ludwig, D.S.; Martin, C.K.; Medin, A.C.; Meijer, E.P.; Morehen, J.C.; Morton, J.P.; Neuhouser, M.L.; Nicklas, T.A.; Ojiambo, R.M.; Pietiläinen, K.H.; Pitsiladis, Y.P.; Plange-Rhule, J.; Plasqui, G.; Prentice, R.L.; Rabinovich, R.A.; Racette, S.B.; Raichlen, D.A.; Ravussin, E.; Reynolds, R.M.; Roberts, S.B.; Schuit, A.J.; Sjödin, A.M.; Stice, E.; Urlacher, S.S.; Valenti, G.; Van Etten, L.M.; Van Mil, E.A.; Wells, JCK; Wilson, G.; Wood, B.M.; Yanovski, J.; Yoshida, T.; Zhang, X.; Murphy-Alford, A.J.; Loechl, C.U.; Melanson, E.L.; Luke, A.H.; Pontzer, H.; Rood, J.; Schoeller, D.A.; Westerterp, K.R.; Wong, W.W.

doi:10.1016/j.xcrm.2021.100203

A standard calculation methodology for human doubly labeled water studies.

Details

Download: 33665639_BIB_160A236A5A5F.pdf (1819.05 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_160A236A5A5F

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

A standard calculation methodology for human doubly labeled water studies.

Journal

Cell reports. Medicine

Author(s)

Speakman J.R., Yamada Y., Sagayama H., Berman ESF, Ainslie P.N., Andersen L.F., Anderson L.J., Arab L., Baddou I., Bedu-Addo K., Blaak E.E., Blanc S., Bonomi A.G., Bouten CVC, Bovet P., Buchowski M.S., Butte N.F., Camps SGJA, Close G.L., Cooper J.A., Creasy S.A., Das S.K., Cooper R., Dugas L.R., Ebbeling C.B., Ekelund U., Entringer S., Forrester T., Fudge B.W., Goris A.H., Gurven M., Hambly C., El Hamdouchi A., Hoos M.B., Hu S., Joonas N., Joosen A.M., Katzmarzyk P., Kempen K.P., Kimura M., Kraus W.E., Kushner R.F., Lambert E.V., Leonard W.R., Lessan N., Ludwig D.S., Martin C.K., Medin A.C., Meijer E.P., Morehen J.C., Morton J.P., Neuhouser M.L., Nicklas T.A., Ojiambo R.M., Pietiläinen K.H., Pitsiladis Y.P., Plange-Rhule J., Plasqui G., Prentice R.L., Rabinovich R.A., Racette S.B., Raichlen D.A., Ravussin E., Reynolds R.M., Roberts S.B., Schuit A.J., Sjödin A.M., Stice E., Urlacher S.S., Valenti G., Van Etten L.M., Van Mil E.A., Wells JCK, Wilson G., Wood B.M., Yanovski J., Yoshida T., Zhang X., Murphy-Alford A.J., Loechl C.U., Melanson E.L., Luke A.H., Pontzer H., Rood J., Schoeller D.A., Westerterp K.R., Wong W.W.

Working group(s)

IAEA DLW database group

ISSN

2666-3791 (Electronic)

ISSN-L

2666-3791

Publication state

Published

Issued date

16/02/2021

Peer-reviewed

Oui

Volume

Number

Pages

100203

Language

english

Notes

Publication types: Journal Article
Publication Status: epublish

Abstract

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO <sub>2</sub> is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO <sub>2</sub> over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

Keywords

doubly labeled water, free-living, total energy expenditure, validation

URN

urn:nbn:ch:serval-BIB_160A236A5A5F6

OAI-PMH

oai:serval.unil.ch:BIB_160A236A5A5F

DOI

10.1016/j.xcrm.2021.100203

Pubmed

33665639

Web of science

000642328900007