Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_1600131B3BBA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy.
Journal
Frontiers in aging neuroscience
Author(s)
Bolton TAW, Van De Ville D., Régis J., Witjas T., Girard N., Levivier M., Tuleasca C.
ISSN
1663-4365 (Print)
ISSN-L
1663-4365
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
14
Pages
873605
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Essential tremor (ET) is the most common movement disorder. Its pathophysiology is only partially understood. Here, we leveraged graph theoretical analysis on structural covariance patterns quantified from morphometric estimates for cortical thickness, surface area, and mean curvature in patients with ET before and one year after (to account for delayed clinical effect) ventro-intermediate nucleus (Vim) stereotactic radiosurgical thalamotomy. We further contrasted the observed patterns with those from matched healthy controls (HCs). Significant group differences at the level of individual morphometric properties were specific to mean curvature and the post-/pre-thalamotomy contrast, evidencing brain plasticity at the level of the targeted left thalamus, and of low-level visual, high-level visuospatial and attentional areas implicated in the dorsal visual stream. The introduction of cross-correlational analysis across pairs of morphometric properties strengthened the presence of dorsal visual stream readjustments following thalamotomy, as cortical thickness in the right lingual gyrus, bilateral rostral middle frontal gyrus, and left pre-central gyrus was interrelated with mean curvature in the rest of the brain. Overall, our results position mean curvature as the most relevant morphometric feature to understand brain plasticity in drug-resistant ET patients following Vim thalamotomy. They also highlight the importance of examining not only individual features, but also their interactions, to gain insight into the routes of recovery following intervention.
Keywords
cortical thickness, essential tremor, graph theory, mean curvature, radiosurgery, stereotactic radiosurgical thalamotomy, structural covariance analysis, surface area
Pubmed
Web of science
Open Access
Yes
Create date
17/06/2022 17:03
Last modification date
08/08/2022 6:08
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