Primary Sarcoma of the Lung - Prognostic Value of Clinicopathological Characteristics of 26 Cases.
Details
Serval ID
serval:BIB_15EF81B04AF1
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Primary Sarcoma of the Lung - Prognostic Value of Clinicopathological Characteristics of 26 Cases.
Journal
Anticancer research
ISSN
1791-7530 (Electronic)
ISSN-L
0250-7005
Publication state
Published
Issued date
03/2020
Peer-reviewed
Oui
Volume
40
Number
3
Pages
1697-1703
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Primary sarcomas of the lung (PSL) represent a rare, largely unknown entity. We herein present a retrospective study of 26 patients diagnosed with PSL.
For a period of 10 years, the records of patients from 5 centers were gathered and analyzed.
Median age at diagnosis was 61.96 years (range=31-75 years). Eight patients (33.33%) had mediastinal node invasion (MNI). From 17 patients (70.83%) with localized disease, 11 patients (64.70%) underwent surgery. Recurrence rate was 72.72%. Median disease-free interval was 15 months. The median overall survival (OS) of patients with metastatic disease was 4 months and 10 months for the whole population. Only surgery had an impact on survival.
Prognosis of PSL is somber. The high proportion of patients with MNI at diagnosis may serve as an indication for surgical evaluation of mediastinum and raises the question whether patients with locoregional PSL should be treated with a more aggressive approach.
For a period of 10 years, the records of patients from 5 centers were gathered and analyzed.
Median age at diagnosis was 61.96 years (range=31-75 years). Eight patients (33.33%) had mediastinal node invasion (MNI). From 17 patients (70.83%) with localized disease, 11 patients (64.70%) underwent surgery. Recurrence rate was 72.72%. Median disease-free interval was 15 months. The median overall survival (OS) of patients with metastatic disease was 4 months and 10 months for the whole population. Only surgery had an impact on survival.
Prognosis of PSL is somber. The high proportion of patients with MNI at diagnosis may serve as an indication for surgical evaluation of mediastinum and raises the question whether patients with locoregional PSL should be treated with a more aggressive approach.
Keywords
Adult, Aged, Female, Humans, Lung Neoplasms/diagnosis, Lung Neoplasms/mortality, Lung Neoplasms/pathology, Male, Middle Aged, Prognosis, Sarcoma/diagnosis, Sarcoma/mortality, Sarcoma/pathology, Survival Rate, Pulmonary sarcoma, epidemiology, prognostic factors, survival
Pubmed
Web of science
Create date
25/04/2020 23:32
Last modification date
21/11/2020 7:26
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