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Lentiviral vectors in Huntington's disease research and therapy
Title of the book
Viral Vectors in Neurobiology and Brain Diseases
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We describe here the potential of viral-mediated gene transfer for the modeling and treatment of Huntington's disease, focusing in particular on strategies for the tissue-specific targeting of various CNS cells. The protocols described here cover the design of lentiviral vectors, strategies for modifying their tropism, including the use of various envelopes and tissue-specific promoters, and the potential of miRNA to regulate transgene expression.
Lentiviral vectors, tissue-specific promoters, pseudotyping, miRNA gene regulation, CNS, Huntington's disease
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