Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird.

Détails

ID Serval
serval:BIB_14DB0B750F96
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird.
Périodique
Biology Letters
Auteur(s)
Récapet C., Sibeaux A., Cauchard L., Doligez B., Bize P.
ISSN
1744-957X (Electronic)
ISSN-L
1744-9561
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
12
Numéro
8
Pages
20160243
Langue
anglais
Résumé
Although disruption of glucose homeostasis is a hallmark of ageing in humans and laboratory model organisms, we have little information on the importance of this process in free-living animals. Poor control of blood glucose levels leads to irreversible protein glycation. Hence, levels of protein glycation are hypothesized to increase with age and to be associated with a decline in survival. We tested these predictions by measuring blood glycated haemoglobin in 274 adult collared flycatchers of known age and estimating individual probability of recapture in the following 2 years. Results show a strong decrease in glycated haemoglobin from age 1 to 5 years and an increase thereafter. Individuals with high levels of glycated haemoglobin had a lower probability of recapture, even after controlling for effects of age and dispersal. Altogether, our findings suggest that poor control of glucose homoeostasis is associated with lower survival in this free-living bird population, and that the selective disappearance of individuals with the highest glycation levels could account for the counterintuitive age-related decline in glycated haemoglobin in the early age categories.
Mots-clé
ageing, diabetes, glycation, survival, collared flycatcher, Ficedula albicollis
Pubmed
Web of science
Création de la notice
16/09/2016 9:44
Dernière modification de la notice
20/08/2019 12:43
Données d'usage