Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes.
Journal of Steroid Biochemistry and Molecular Biology
The peroxisome proliferator-activated receptors (PPAR) alpha, beta/delta and gamma belong to the nuclear hormone receptor superfamily. As ligand-activated receptors, they form a functional transcriptional unit upon heterodimerization with retinoid X receptors (RXRs). PPARs are activated by fatty acids and their derivatives, whereas RXR is activated by 9-cis retinoic acid. This heterodimer binds to peroxisome proliferator response elements (PPRE) residing in target genes and stimulates their expression. Recent reports now indicate that PPARs and RXRs can function independently, in the absence of a hetero-partner, to modulate gene expression. Of importance, these non-canonical mechanisms underscore the impact of both cofactors and DNA on gene expression. Furthermore, these different mechanisms reveal the increasing repertoire of PPAR 'target' genes that now encompasses non-PPREs containing genes. It is also becoming apparent that understanding the regulation of PPAR expression and activity, can itself have a significant influence on how the expression of subgroups of target genes is studied and integrated in current knowledge.
Animals, Gene Expression Regulation, Hormones, Humans, Models, Biological, Peroxisome Proliferator-Activated Receptors, Receptors, Cytoplasmic and Nuclear, Retinoid X Receptors, Transforming Growth Factor beta, Transforming Growth Factor beta1, Tumor Necrosis Factor-alpha, Wound Healing
Web of science
Last modification date