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Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.
Interleukin 7 is essential for the survival of naive T lymphocytes. Despite its importance, its cellular source in the periphery remains poorly defined. Here we report a critical function for lymph node access in T cell homeostasis and identify T zone fibroblastic reticular cells in these organs as the main source of interleukin 7. In vitro, T zone fibroblastic reticular cells were able to prevent the death of naive T lymphocytes but not of B lymphocytes by secreting interleukin 7 and the CCR7 ligand CCL19. Using gene-targeted mice, we demonstrate a nonredundant function for CCL19 in T cell homeostasis. Our data suggest that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4(+) and CD8(+) T cell homeostasis by providing a limited reservoir of survival factors.
Adoptive Transfer, Animals, Cell Survival, Chemokine CCL19/immunology, Chemokine CCL19/metabolism, Fibroblasts/metabolism, Flow Cytometry, Fluorescent Antibody Technique, Gene Expression, Homeostasis/immunology, In Situ Hybridization, Interleukin-7/biosynthesis, Lymph Nodes/cytology, Lymph Nodes/immunology, Mice, Mice, Inbred C57BL, RNA, Messenger/analysis, Reverse Transcriptase Polymerase Chain Reaction, T-Lymphocytes/cytology, T-Lymphocytes/immunology
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