Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.

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Serval ID
serval:BIB_1474CB275A42
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Production externe
Title
Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.
Journal
Nature neuroscience
Author(s)
Conductier G. (co-first), Brau F. (co-first), Viola A. (co-first), Langlet F., Ramkumar N., Dehouck B., Lemaire T., Chapot R., Lucas L., Rovère C., Maitre P., Hosseiny S., Petit-Paitel A., Adamantidis A., Lakaye B., Risold P.Y., Prévot V., Meste O., Nahon J.L., Guyon A.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Publication state
Published
Issued date
07/2013
Peer-reviewed
Oui
Volume
16
Number
7
Pages
845-847
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
Publication Status: ppublish
Abstract
Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
Keywords
Adenosine Triphosphate/pharmacology, Animals, Brain/cytology, Calcium/metabolism, Cerebral Ventricles/anatomy & histology, Cerebral Ventricles/drug effects, Cerebrospinal Fluid/drug effects, Cerebrospinal Fluid/metabolism, Cilia/drug effects, Cilia/physiology, Electric Stimulation, Ependyma/anatomy & histology, Female, Hormone Antagonists/pharmacology, Hypothalamic Hormones/deficiency, Hypothalamic Hormones/pharmacology, In Vitro Techniques, Male, Melanins/deficiency, Melanins/pharmacology, Mice, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins/metabolism, Neurons/drug effects, Neurons/metabolism, Pituitary Hormones/deficiency, Pituitary Hormones/pharmacology, Receptors, Somatostatin/deficiency, Receptors, Somatostatin/genetics, Serotonin/pharmacology
DOI
10.1038/nn.3401
Pubmed
23708141
Web of science
000321180900015
Create date
07/08/2022 14:58
Last modification date
13/10/2023 9:32
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