Neurotrophic receptor tyrosine kinase family members in secretory and non-secretory breast carcinomas.

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Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_145ED5AE75A7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neurotrophic receptor tyrosine kinase family members in secretory and non-secretory breast carcinomas.
Journal
World journal of clinical oncology
Author(s)
Stravodimou A., Voutsadakis I.A.
ISSN
2218-4333 (Print)
ISSN-L
2218-4333
Publication state
Published
Issued date
24/02/2022
Peer-reviewed
Oui
Volume
13
Number
2
Pages
135-146
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Breast cancer is the most common female cancer and a major cause of morbidity and mortality. Progress in breast cancer therapeutics has been attained with the introduction of targeted therapies for specific sub-sets. However, other subsets lack targeted interventions and thus there is persisting need for identification and characterization of molecular targets in order to advance breast cancer therapeutics.
To analyze the role of lesions in neurotrophic receptor tyrosine kinase (NTRK) genes in breast cancers.
Analysis of publicly available genomic breast cancer datasets was performed for identification and characterization of cases with fusions and other molecular abnormalities involving NTRK1, NTRK2 and NTRK3 genes.
NTRK fusions are present in a small number of breast cancers at the extensive GENIE project data set which contains more than 10000 breast cancers. These cases are not identified as secretory in the database, suggesting that the histologic characterization is not always evident. In the breast cancer The Cancer Genome Atlas (TCGA) cohort the more common molecular lesion in NTRK genes is amplification of NTRK1 observed in 7.9% of breast cancers.
Neurotrophin receptors molecular lesions other than fusions are observed more often than fusions. However, currently available NTRK inhibitors are effective mainly for fusion lesions. Amplifications of NTRK1, being more frequent in breast cancers, could be a viable therapeutic target if inhibitors efficacious for them become available.
Keywords
Amplifications, Breast cancer, Fusions, Neurotrophic receptor tyrosine kinases, Tropomyosin related kinases
Pubmed
Web of science
Open Access
Yes
Create date
06/04/2022 20:07
Last modification date
25/01/2024 7:31
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