Potassium restores vasorelaxation of resistance arterioles in non-hypertensive DOCA/salt fed mice.

Details

Serval ID
serval:BIB_144C760DE345
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Potassium restores vasorelaxation of resistance arterioles in non-hypertensive DOCA/salt fed mice.
Journal
Microvascular Research
Author(s)
Wyss C., Wang Q., Golshayan D., Nussberger J., Burnier M., Lehr H.A., Schaefer S.C.
ISSN
1095-9319 (Electronic)
ISSN-L
0026-2862
Publication state
Published
Issued date
2012
Volume
84
Number
3
Pages
340-344
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
BACKGROUND: Potassium-enriched diets exert renal and cardiovascular protective effects, but the underlying mechanisms are largely unknown.
METHODS: Using the dorsal skinfold chamber model for intravital microscopy, we examined endothelium-dependent vasorelaxation of precapillary resistance arterioles in response to acetylcholine or the NO donor SNAP in awake mice. Experiments were performed in uni-nephrectomized one renin gene (Ren-1c) C57BL/6 mice (control group) and in mice having received a continuous administration of deoxycorticosterone acetate and a dietary supplementation of 1% sodium chloride for 8weeks (DOCA/salt group). An additional group of DOCA/salt treated animals received a dietary supplement of 0.4% KCl for 3weeks prior to the experiments (DOCA/salt + potassium group).
RESULTS: DOCA/salt treatment for 8weeks resulted in hypokalemia, but blood pressure remained unchanged. In DOCA/salt mice, relaxation of resistance arterioles was blunted in response to acetylcholine, and to a lesser extent to SNAP, suggesting endothelial dysfunction. Endothelium-dependent vasorelaxation was restored by the potassium-enriched diet.
CONCLUSION: This study is the first to demonstrate a protective effect of potassium on endothelium-dependent vasorelaxation in the absence of confounding anti-hypertensive effects, as observed in most animal models and the clinical situation. We propose that the known cardio- and nephro-protective effects of potassium might - at least in part - be mediated by the salutary effects on endothelium-dependent arteriolar relaxation.
Pubmed
Web of science
Create date
07/11/2012 14:58
Last modification date
20/08/2019 12:43
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