Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_1406CC096C11
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase.
Journal
Current Opinion in Chemical Biology
Author(s)
Hailfinger S., Lenz G., Thome M.
ISSN
1879-0402 (Electronic)
ISSN-L
1367-5931
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
23C
Pages
47-55
Language
english
Abstract
The paracaspase MALT1 is an Arg-specific protease that cleaves multiple substrates to promote lymphocyte proliferation and survival. The catalytic activity of MALT1 is normally tightly regulated by antigen receptor triggering, which promotes MALT1 activation by its inducible monoubiquitination-dependent dimerization. Constitutive MALT1 activity is a hallmark of specific subsets of B-cell lymphomas, which are characterized by chromosomal translocations or point mutations that activate MALT1 or its upstream regulators. Recent findings suggest that such lymphomas may be sensitive to treatment with MALT1 inhibitors. Here we review recent progress in the understanding of MALT1 function and regulation, and the development of small molecule MALT1 inhibitors for therapeutic applications.
Pubmed
Web of science
Open Access
Yes
Create date
15/12/2014 14:44
Last modification date
20/08/2019 12:42
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