BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors.
Details
Download: 2022 BAFFR BCR in naive B cells.pdf (5249.21 [Ko])
State: Public
Version: author
License: CC BY-NC-ND 4.0
State: Public
Version: author
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_13E73B5B8C0A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors.
Journal
Cell reports
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
28/06/2022
Peer-reviewed
Oui
Volume
39
Number
13
Pages
111019
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory B cells seem to survive without BAFF. Here, we show that BAFF activates PI3K/AKT only in naive B cells and changes the expression of genes regulating migration, proliferation, growth, and survival. BAFF-induced PI3K/AKT activation requires direct interactions between BAFFR and the B cell antigen receptor (BCR) components CD79A and CD79B and is enhanced by the AKT coactivator TCL1A. Compared to memory B cells, naive B cells express more surface BCRs, which interact better with BAFFR than IgG or IgA, thus allowing stronger responses to BAFF. As ablation of BAFFR in naive and memory B cells causes cell death independent of BAFF-induced signaling, BAFFR seems to act also as an intrinsic factor for B cell survival.
Keywords
B-Cell Activating Factor/immunology, B-Cell Activating Factor/metabolism, B-Cell Activation Factor Receptor/immunology, B-Cell Activation Factor Receptor/metabolism, Humans, Memory B Cells/immunology, Memory B Cells/metabolism, Phosphatidylinositol 3-Kinases/immunology, Phosphatidylinositol 3-Kinases/metabolism, Proto-Oncogene Proteins c-akt/immunology, Proto-Oncogene Proteins c-akt/metabolism, Receptors, Antigen, B-Cell/immunology, Receptors, Antigen, B-Cell/metabolism, BAFF, BAFFR, BCR, CP: Immunology, PI3K signaling, human memory B cells
Pubmed
Web of science
Open Access
Yes
Create date
13/07/2022 11:49
Last modification date
11/03/2023 6:44