Corticofugal modulation of functional connectivity within the auditory thalamus of rat, guinea pig and cat revealed by cooling deactivation.

Details

Serval ID
serval:BIB_13935
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Corticofugal modulation of functional connectivity within the auditory thalamus of rat, guinea pig and cat revealed by cooling deactivation.
Journal
Journal of Neuroscience Methods
Author(s)
Villa A.E., Tetko I.V., Dutoit P., De Ribaupierre Y., De Ribaupierre F.
ISSN
0165-0270
Publication state
Published
Issued date
1999
Volume
86
Number
2
Pages
161-178
Language
english
Abstract
Microelectrode recordings were simultaneously performed at multiple sites in the medial geniculate body (MGB) of anesthetized cats, rats and guinea pigs. We studied the effect of cortical deactivation on the association of neural activity within the thalamus during spontaneous activity. The corticofugal influence was suppressed by temporary cooling of the auditory cortex. Pairs of spike trains recorded from the same electrode were distinguished from cases where units were in MGB but recorded with different electrodes. Time domain analyses included crosscorrelations and search for precise repetition of complex spatiotemporal firing patterns of reverberating thalamic circuits. As a complementary approach we performed bispectral analyses of simultaneously recorded local field potentials in order to uncover the frequency components of their power spectra which are non linearly coupled. All results suggest that new functional neuronal circuits might appear at the thalamic level in the absence of input from the cortex. The newly active intrathalamic connections would provide the necessary input to sustain the reverberating activity of thalamic cell assemblies and generate low frequency non-linear interactions. The dynamic control exerted by the cortex over the functional segregation of information processing carried out in the thalamus conforms with theoretical neural network studies and with the functional selectivity-adaptive filtering theory of thalamic neuronal assemblies. Although this general conclusion remains valid across species, specific differences are discussed in the frame of known differences of the microcircuitry elements.
Keywords
Animals, Auditory Cortex/cytology, Auditory Cortex/physiology, Auditory Pathways/cytology, Auditory Pathways/physiology, Cats, Cell Separation, Cold Temperature, Electrophysiology, Guinea Pigs, Neurons/physiology, Rats, Thalamus/cytology, Thalamus/physiology
Pubmed
Web of science
Create date
19/11/2007 13:06
Last modification date
20/08/2019 13:42
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