Gender differences in cancer patients with acute venous thromboembolism.
Details
Serval ID
serval:BIB_130AF90F60B8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gender differences in cancer patients with acute venous thromboembolism.
Journal
Thrombosis Research
Working group(s)
RIETE Investigators
Contributor(s)
Monreal M., Decousus H., Prandoni P., Brenner B., Barba R., Di Micco P., Bertoletti L., Schellong S., Papadakis M., Tzoran I., Reis A., Bosevski M., Bounameaux H., Malý R., Adarraga MD., Alvarado AV., Arcelus JI., Barba M., Barrón M., Barrón-Andrés B., Bascuñana J., Benítez JF., Blanco-Molina A., Casado I., Conget F., Chaves EL., de Ancos C., del Molino F., del Toro J., Falgá C., Farfán AI., Fernández-Capitán C., Font L., Gallego P., García-Bragado F., Gómez V., González J., González-Marcano D., Grau E., Guijarro R., Gutiérrez J., Hernández L., Hernández-Huerta S., Jara-Palomares L., Jaras MJ., Jiménez D., Lecumberri R., Lobo JL., López-Jiménez L., López-Montes L., López-Reyes R., López-Sáez JB., Lorente MA., Lorenzo M., Luque JM., Madridano O., Marchena PJ., Martín-Antorán JM., Mellado M., Monreal M., Morales MV., Nauffal D., Nieto JA., Núñez MJ., Otero R., Pagán B., Pedrajas JM., Peris ML., Pons I., Porras JA., Puerta P., Riera-Mestre A., Rivas A., Rodríguez-Dávila MA., Román P., Rosa V., Ruiz-Giménez N., Ruiz J., Samperiz A., Sánchez R., Soler S., Soto MJ., Suriñach JM., Tiberio G., Tilvan RM., Tirado R., Trujillo-Santos J., Uresandi F., Valero B., Valle R., Vela J., Villalobos A., Malfante P., Matías V., Vivero F., Verhamme P., Peerlinck K., Wells P., Malý R., Hirmerova J., Salgado E., Bertoletti L., Bura-Riviere A., Moustafa F., Farge-Bancel D., Hij A., Mahe I., Merah A., Quere I., Schellong S., Babalis D., Papadakis M., Tzinieris I., Braester A., Brenner B., Tzoran I., Zeltser D., Amitrano M., Apollonio A., Barillari G., Cannavaccioulo F., Ciammaichella M., Dentali F., Di Micco P., Enea I., Guida A., Maida R., Pace F., Pasca S., Pesavento R., Piovella C., Prandoni P., Rota L., Tiraferri E., Tufano A., Visonà A., Mesquita P., Ribeiro de Almeida JL. , Sousa MS., Bosevski M., Zdraveska M., Alatri A., Bounameaux H., Calanca L., Mazzolai L., Serrano JC.
ISSN
1879-2472 (Electronic)
ISSN-L
0049-3848
Publication state
Published
Issued date
2015
Volume
135 Suppl 1
Pages
S12-S15
Language
english
Notes
Alatri A is a RIETE investigator
Abstract
BACKGROUND: The outcome of cancer patients with acute venous thromboembolism (VTE) may differ according to gender.
METHODS: We used the RIETE database to compare the rate of VTE (pulmonary embolism [PE] or deep vein thrombosis [DVT]) recurrences), major bleeding and mortality during the course of anticoagulation, according to gender.
RESULTS: As of August 2014, 11,055 patients with active cancer were enrolled in RIETE, of whom 5,104 (46%) were women. During the course of anticoagulation (mean: 142 days), 505 patients developed recurrent VTE, 429 bled and 2730 died. Compared with men, women had a significantly lower rate of fatal bleeding (risk ratio [RR]: 0.69; 95% CI: 0.47-0.99) and death (RR: 0.90; 95% CI: 0.83-0.97), and a non-significantly lower rate of PE recurrences (RR 0.83; 95% CI: 0.65-1.06) and major bleeding (RR: 0.89; 95% CI: 0.74-1.08).
CONCLUSIONS: During the course of anticoagulation, cancer women with VTE had a better outcome than men.
METHODS: We used the RIETE database to compare the rate of VTE (pulmonary embolism [PE] or deep vein thrombosis [DVT]) recurrences), major bleeding and mortality during the course of anticoagulation, according to gender.
RESULTS: As of August 2014, 11,055 patients with active cancer were enrolled in RIETE, of whom 5,104 (46%) were women. During the course of anticoagulation (mean: 142 days), 505 patients developed recurrent VTE, 429 bled and 2730 died. Compared with men, women had a significantly lower rate of fatal bleeding (risk ratio [RR]: 0.69; 95% CI: 0.47-0.99) and death (RR: 0.90; 95% CI: 0.83-0.97), and a non-significantly lower rate of PE recurrences (RR 0.83; 95% CI: 0.65-1.06) and major bleeding (RR: 0.89; 95% CI: 0.74-1.08).
CONCLUSIONS: During the course of anticoagulation, cancer women with VTE had a better outcome than men.
Keywords
Acute Disease, Aged, Anticoagulants/therapeutic use, Comorbidity, Female, Hemorrhage/mortality, Humans, Incidence, Male, Neoplasms/mortality, Risk Factors, Sex Characteristics, Sex Distribution, Spain/epidemiology, Survival Rate, Treatment Outcome, Venous Thromboembolism/drug therapy, Venous Thromboembolism/mortality
Pubmed
Web of science
Create date
12/02/2016 13:50
Last modification date
28/05/2020 5:26
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